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Cephalosporin-Tobramycin Activity Against Enterococci

  • F. R. Fekety
  • B. Bruce
  • D. Turrell
  • C. Work
  • J. Conway
Part of the Chemotherapy book series (CT, volume 3)

Summary

Anti-enterococcal synergism was readily demonstrable when cefazolin or cephalothin were combined with gentamicin or tobramycin, and Str. faecalis isolates were killed rapidly at attainable serum concentrations. The cephalosporins combined with amikacin were rarely synergistic, but ampicillin-amikacin was synergistic and bactericidal. Some of these newer combinations are worthy of further study in enterococcal infections.

Keywords

Michigan Medical Enterococcal Infection Enterococcus Isolate Michigan Medical School Bactericidal Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Fekety, F.R. and Weiss, P. Antimicrob. Agents and Chemotherapy-1966, p. 156.Google Scholar
  2. Harwick, H.J., Weiss, P., and Fekety, F.R. (1968), J. Lab. Clin. Med. 72: 511.PubMedGoogle Scholar
  3. Kirby, W.M.M. and Regamey, C. (1973), J. Inf. Dis. 128: S341.CrossRefGoogle Scholar
  4. Lacey, B.W. Mechanisms of Chemotherapeutic Synergy. In The Strategy of Chemotherapy, Cambridge University Press, London, 1958, p. 247.Google Scholar
  5. Weinstein, A.J. and Moellering, R.C. (1975), Antimicrob. Agents and Chemother. 7: 522.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • F. R. Fekety
    • 1
  • B. Bruce
    • 1
  • D. Turrell
    • 1
  • C. Work
    • 1
  • J. Conway
    • 1
  1. 1.Department of Internal MedicineUniversity of Michigan Medical SchoolAnn ArborUSA

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