Cephalosporin-Tobramycin Activity Against Enterococci
Anti-enterococcal synergism was readily demonstrable when cefazolin or cephalothin were combined with gentamicin or tobramycin, and Str. faecalis isolates were killed rapidly at attainable serum concentrations. The cephalosporins combined with amikacin were rarely synergistic, but ampicillin-amikacin was synergistic and bactericidal. Some of these newer combinations are worthy of further study in enterococcal infections.
KeywordsPenicillin Streptomycin Ampicillin Vancomycin Gentamicin
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- Fekety, F.R. and Weiss, P. Antimicrob. Agents and Chemotherapy-1966, p. 156.Google Scholar
- Lacey, B.W. Mechanisms of Chemotherapeutic Synergy. In The Strategy of Chemotherapy, Cambridge University Press, London, 1958, p. 247.Google Scholar
- Weinstein, A.J. and Moellering, R.C. (1975), Antimicrob. Agents and Chemother. 7: 522.Google Scholar