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Relationships between Inhibition of Nucleic Acids Synthesis and Competence in B. subtilis

  • M. T. Perez-Ureña
  • E. Garcia
  • M. Espinosa
  • A. Portoles
Part of the Chemotherapy book series (CT, volume 3)

Summary

The effect of four antibiotic inhibitors of nucleic acid synthesis on a stimulated competence system of B. subtilis have been studied. The most active inhibitory effect was exhibited by the drugs that inhibit the m-RNA synthesis by intercalating in the DNA (actinomycin D) or by inhibiting the RNA-polymerase (rifamycin). No effect could be observed when nalidixic acid was tested.

Keywords

Nalidixic Acid Minimal Inhibitory Concentration Competence Development Nucleic Acid Synthesis Bacterial Transformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. T. Perez-Ureña
    • 1
  • E. Garcia
    • 1
  • M. Espinosa
    • 1
  • A. Portoles
    • 1
  1. 1.Inst. “Jaime Ferrán” of MicrobiologyC.S.I.C.MadridSpain

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