Relationships between Inhibition of Nucleic Acids Synthesis and Competence in B. subtilis
The effect of four antibiotic inhibitors of nucleic acid synthesis on a stimulated competence system of B. subtilis have been studied. The most active inhibitory effect was exhibited by the drugs that inhibit the m-RNA synthesis by intercalating in the DNA (actinomycin D) or by inhibiting the RNA-polymerase (rifamycin). No effect could be observed when nalidixic acid was tested.
KeywordsNalidixic Acid Minimal Inhibitory Concentration Competence Development Nucleic Acid Synthesis Bacterial Transformation
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