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Action of Polyene Macrolide Antibiotics on Protoplast Type L-form of E. Coli

  • I. Haupt
  • H. Thrum
  • E. Schuhmann
  • R. Geuther
Part of the Chemotherapy book series (CT, volume 3)

Abstract

Polyene macrolide antibiotics are known to exhibit biological activity against fungi and other eukarytic organisms, but not against bacteria These antibiotics cause permeability alterations in sensitive cells which lead to the loss of cytoplasmatic constituents culminating in cell death. The selective toxicity of polyene antibiotics is due to interaction with a unique component, a sterol, in the membranes of sensitive organisms. The natural resistance of bacteria on the other hand is generally explained by the absence of sterols in the bacterial cell membranes. In contrast to results of other investigators we found a real antibacterial activity with several polyene antibiotics by using the stable protoplast type L-form of E. coli W1655F+ as a test organism.

Keywords

Macrolide Antibiotic Sterol Content Bacterial Cell Membrane Selective Toxicity Permeability Alteration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • I. Haupt
    • 1
  • H. Thrum
  • E. Schuhmann
    • 1
  • R. Geuther
    • 1
  1. 1.Zentralinstitut für Mikrobiologie und experimentelle Therapie der AdW der DDRJenaGerman Democratic Republic

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