Summary
The mode of action of flucytosine (5-FC, 5-fluorocytosine) in Aspergillus fumigatus and Aspergillus niger was studied. Pyrimidines, purines and nucleosides were found to have an antagonistic effect on 5-FC activity and evidence for a common purine-pyrimidine uptake system was found. Only a small amount, 7 to 17 per cent, of 5-FC taken up by the aspergilli was incorporated in RNA and none was incorporated in DNA. DNA content of cells grown in the presence of 5-FC was from 4 to 10 times that of control cells. These data are not compatible with the scheme proposed for the mode of action of 5-FC in yeasts and it is suggested that 5-FC in the Aspergilli may inhibit DNA synthesis.
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References
Atkinson, W. and H.L. Israel (1973). Am. J. Med. 55, 496.
Polak, A. and Scholer, H.J. (1973). Path. Microbiol. 39, 334.
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© 1976 Plenum Press, New York
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Wagner, G., Shadomy, S. (1976). Mode of Action of Flucytosine in Aspergillus Species. In: Williams, J.D., Geddes, A.M. (eds) Special Problems in Chemotherapy. Chemotherapy, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3120-9_34
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DOI: https://doi.org/10.1007/978-1-4684-3120-9_34
Publisher Name: Springer, Boston, MA
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