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Mode of Action of Flucytosine in Aspergillus Species

  • Gerald Wagner
  • Smith Shadomy
Part of the Chemotherapy book series (CT, volume 3)

Summary

The mode of action of flucytosine (5-FC, 5-fluorocytosine) in Aspergillus fumigatus and Aspergillus niger was studied. Pyrimidines, purines and nucleosides were found to have an antagonistic effect on 5-FC activity and evidence for a common purine-pyrimidine uptake system was found. Only a small amount, 7 to 17 per cent, of 5-FC taken up by the aspergilli was incorporated in RNA and none was incorporated in DNA. DNA content of cells grown in the presence of 5-FC was from 4 to 10 times that of control cells. These data are not compatible with the scheme proposed for the mode of action of 5-FC in yeasts and it is suggested that 5-FC in the Aspergilli may inhibit DNA synthesis.

Keywords

Minimal Inhibitory Concentration Aspergillus Niger Candida Albicans Aspergillus Fumigatus Minimal Inhibitory Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Atkinson, W. and H.L. Israel (1973). Am. J. Med. 55, 496.Google Scholar
  2. Polak, A. and Scholer, H.J. (1973). Path. Microbiol. 39, 334.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Gerald Wagner
    • 1
  • Smith Shadomy
    • 1
  1. 1.Departments of Medicine and Microbiology, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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