Oral Treatment of Vaginal Trichomoniasis with Ornidazole, a Derivative of Metronidazole

Summary

Results of the use of ∝ chloromethyl-2-methyl-5-nitroimidazole-ethanol in different schedules of oral administration for the treatment of trichomoniasis in couples affected by the parasitic infestation are informed. In a first group of 20 couples were treated with metronidazole. Clinical and parasitological controls were carried out up to the second menstruation after treatment. Very satisfactory results with no relapses were obtained In this group only oral medication was used.

In a second group of 60 couples, 2 g. of the compound were given in 2 doses in a single day treatment adding one vaginal tablet of 500 mg., twice, every 12 hours. Results were excellent as all clinical manifestation in both partners disappeared in 24 to 72 hours. Parasitoscopic studies were negative in 57 couples, with 3 relapses. A second treatment gave immediate satisfactory results in all these cases.

A third group of 30 couples which was given one single oral dose of 2 g. and 1 vaginal application showed excellent results in 3 of these after one month’s treatment and 27 couples after 2 months’ treatment.

Trichomonad findings were negative in 28 cases and 2 relapses were observed 2 months after treatment. A second treatment gave immediate excellent results.

In the relapsed cases of the two groups, it was impossible to determine whether other partners were involved.