Adverse Reactions to Intermittent Rifampicin
Adverse reactions to the commonly used dosage schedules of rifampicin are more frequent during intermittent than during daily chemotherapy, the commonest being a febrile reaction called the ‘flu’ syndrome which rarely occurs during daily treatment. During intermittent chemotherapy, the syndrome is less common with lower dosage schedules, less common during twice-weekly than during once-weekly treatment with the same dose size, less common when intermittent treatment is preceded by a daily phase and less common when small daily doses of rifampicin are given in addition to the larger intermittent doses. It is associated with circulating rifampicin-dependent antibodies and occurs during the period of high serum rifampicin concentration and reduced antibody concentration after an intermittent dose of the drug. It probably has an immunological origin.
KeywordsAdverse Reaction Dose Size British Medical Research Council Daily Phase Intermittent Chemotherapy
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