Surface Structures and Antibiotic Targets in the Gonococcus

  • M. R. J. Salton
  • K. S. Kim
  • R. Davis
  • K. Y. Cho
Part of the Chemotherapy book series (CT, volume 3)


All four colony types of N. gonorrhoeae possess pit-like structures in the outer membrane of their envelopes. A stable, piliated strain GC1 of intermediate colony morphology also possesses this structural feature. Isolated envelopes of gonococcal strain GC1 and T1 have an active D-alanine carboxypeptidase. This membrane-bound enzyme in GC1 has an alkaline pH optimum, a Km of 0. 25 mM and is sensitive to inhibition by penicillin G, ampicillin, cloxacillin and methicillin. An active phospholipase A is present in GC1, Ti and T4 envelopes, the activity is stimulated by methanol (30%) and the enzyme converts phosphatidylethanolamine to lysophosphatidylethanolamine. It is suggested that such an enzyme could modulate barrier properties of the outer membrane.


Outer Membrane Neisseria Gonorrhoeae Colony Type Veronal Buffer Antibiotic Target 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. R. J. Salton
    • 1
  • K. S. Kim
    • 1
  • R. Davis
    • 1
  • K. Y. Cho
    • 1
  1. 1.New York University School of MedicineNew YorkUSA

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