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Rate of Sterilization of Sputum from Patients with Pulmonary Tuberculosis

  • Gladys L. Hobby
  • H. William Harris
  • Charles Felton
  • John Edsall
Part of the Chemotherapy book series (CT, volume 3)

Abstract

In 1973 , as part of a study to evaluate the usefulness of a procedure developed by us for precise microscopic enumeration of acid-fast bacilli in the sputum of patients with pulmonary tuber­culosis, the number of culturable mycobacterial cell units per ml. of sputum was determined in 28 patients before and during chemo­therapy. The data obtained clearly showed, perhaps for the first time, that there is a very significant decrease in the acid-fast burden, at least in some patients, during the first two weeks of treatment. The data further suggested that quantitation of the culturable mycobacterial burden might well provide a useful mech­anism for comparison of chemotherapeutic drug regimens. The present study was prompted by these observations.

Keywords

Pulmonary Tuberculosis Antituberculosis Drug Chronic Hepatic Disease Tuberculous Patient Microbial Burden 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Gladys L. Hobby
    • 1
  • H. William Harris
    • 2
  • Charles Felton
    • 3
  • John Edsall
    • 3
  1. 1.Veterans Administration HospitalEast OrangeUSA
  2. 2.Bellevue HospitalNew YorkUSA
  3. 3.Harlem HospitalNew YorkUSA

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