Abstract
The capability of an extract of the Calabar bean to antagonize the mydriatic effect of atropine was known to Kleinwachter who introduced antidote treatment of overdosage with anticholinergic drugs in 1864 (18). In 2 out of 4 prisoners who drank a solution of atropine stolen in his hospital he described several symptoms of “the central anticholinergic syndrome” (20) as well as the therapeutic effect of oral administration of a Calabar-extract (18). In the same year a pure alkaloid was isolated from the West African bean by Jobst and Hesse and named physostigmine (19).
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References
Albanus, L. (1970): FOA Rept. 4:1–17.
Alven, G., Ericson, A. and Westerholm, B. (1977): Lakartidningen 74:315–317.
Aquilonius, S.-M. and Hedstrand, U. (1977): Acta Anesth. Scand. (in press).
Bartolini, A., Bartolini, R. and Domino, E.F. (1973): Neuropharmacology 12:15–25.
Bernhards, W. (1973): Anesth. Anal. 52:938–941.
Brown, T. C.K. (1976): Clin. Toxicol. 9:255–272.
Carpenter, W. T. (1976): Arch. Ophthalmol. 78:445–447.
Crowell, E.B. and Ketchum, J. S. (1967): Clin. Pharmacol. Ther. 8:409–414.
Davies, R.K., Tucker, G.J., Harrow, M. and Detre, T. P. (1971): Amer. J. Psychiat. 128:127–131.
Duvoisin, R. C. and Katz, R. (1968): JAMA 206:1963–1965.
El-Yousef, M.K., Janowsky, D.S., Davis, J.M. and Sekerke, J.H. (1973): Amer. J. Psychiat. 130:141–145.
Faletta, J.M., Stasney, C.R. and Mintz, A.A. (1970): South Med. J. 63:1492–1493.
Forrer, G.R. and Miller, J.J. (1958): Amer. J. Psychiat. 115:455–458.
Granacher, R. P. and Baldessarini, R. J. (1976): In: Clinical Neuropharmacology, Vol.1, (Ed.) H.L. Klawans, Raven Press, New York.
Heiser, J. F. and Wilbert, D.E. (1974): Amer. J. Psychiat. 131:1275–1277.
Holinger, P.C. and Klawans, H.L. (1976): Amer. J. Psychiat. 133:1018–1023.
Ketchum, J.S., Sidell, F.R., Crowell, E.B., Aghajanian, G.K. and Hayes, A.H. (1973): Psychopharmacologia 28:121–145.
Kleinwachter, (1864): Klin. Wschr. (Berlin) 369–371.
Koelle, G.B. (1975): In: The Pharmacological Basis of Therapeutics: Anticholinesterase Agents, (Eds.) A. Goodman and E. Gilman, MacMillan, New York.
Longo, V.G. (1966): Pharmacol. Rev. 18:965–996.
Matthew, H. and Lawson, A.A.H. (Eds.) (1974): Treatment of Common Acute Poisonings, Churchill and Livingston, Edinburgh.
Newton, R.W. (1975): JAMA 231:941–943.
Rumack, B.H. (1973): Pediatrics 52:449–451.
Schuster, P., Gabriel, E., Kufferle, B. and Karobath, M. (1976): Lancet 1:37–38.
Slovis, T.L., Ott, J. E., Teitelbaum, D. T. and Lipscomb, W. (1971): Clin. Toxicol. 4:451–459.
Smiler, B. G., Bartholomew, E.G., Sivak, B.J., Alexander, C. D. and Brown, E.M. (1973): Amer. J. Obstet. Gynecol. 116:326–329.
Smith, D.B., Clark, R. B., Stephens, S.R., Sherman, R. L. and Marshall, L.H. (1976): Anesth. Anal. 55:478–480.
Snyder, B.C., Blonde, L. and McWhirter, W.R. (1974): JAMA 230:1433–1434.
Snyder, S., Greenberg, D. and Yamamura, H. (1974): Arch. Gen. Psychiat. 31:58–61.
Spiker, D.G., Weiss, A.N., Chang, S.S., Rutwitch, J. F. and Biggs, J.T. (1975): Clin. Pharmacol. Ther. 18:539–546.
Ullman, K. C., Groh, R.H. and Wolff, F.W. (1970): Lancet 1:252.
Young, S.E., Ruiz, R. S. and Faletta, J. (1971): Amer. J. Ophthalmol. 78:445–447.
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Aquilonius, SM. (1978). Physostigmine in the Treatment of Drug Overdose. In: Jenden, D.J. (eds) Cholinergic Mechanisms and Psychopharmacology. Advances in Behavioral Biology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3096-7_56
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DOI: https://doi.org/10.1007/978-1-4684-3096-7_56
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