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Cholinergic Dysfunction in Mania and Movement Disorders

  • K. L. Davis
  • P. A. Berger
  • L. E. Hollister
  • J. R. DoAmaral
  • J. D. Barchas
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)

Abstract

Clinical investigations on the role of cholinergic mechanisms in neurological and psychiatric disorders have been facilitated by at least three important advances. The first is the increasing elucidation of the role of brain ACh by basic scientists. The improved assays for Ch and ACh in biological fluids have also improved clinical studies. Finally, the use of the physostigmine infusion to increase central cholinergic activity in human subjects has become an important investigational tool. These studies have strengthened the conviction of some investigators that relative cholinergic underactivity may play a role in some neuropsychiatric disorders.

Keywords

Tardive Dyskinesia Involuntary Movement Brief Psychiatric Rate Scale Movement Frequency Choline Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • K. L. Davis
    • 1
    • 2
  • P. A. Berger
    • 1
    • 2
  • L. E. Hollister
    • 1
    • 2
  • J. R. DoAmaral
    • 2
  • J. D. Barchas
    • 2
  1. 1.Veterans Administration HospitalPalo AltoUSA
  2. 2.Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA

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