Cholinergic Dysfunction in Mania and Movement Disorders

  • K. L. Davis
  • P. A. Berger
  • L. E. Hollister
  • J. R. DoAmaral
  • J. D. Barchas
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


Clinical investigations on the role of cholinergic mechanisms in neurological and psychiatric disorders have been facilitated by at least three important advances. The first is the increasing elucidation of the role of brain ACh by basic scientists. The improved assays for Ch and ACh in biological fluids have also improved clinical studies. Finally, the use of the physostigmine infusion to increase central cholinergic activity in human subjects has become an important investigational tool. These studies have strengthened the conviction of some investigators that relative cholinergic underactivity may play a role in some neuropsychiatric disorders.


Tardive Dyskinesia Involuntary Movement Brief Psychiatric Rate Scale Movement Frequency Choline Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Aquilonius, S.-M., Eckernas, S.A. (1975): New Eng. J. Med. 293; 1105–1106.PubMedGoogle Scholar
  2. 2.
    Aquilonius, S.-M., Nystrom, B., Schuberth, J. and Sundwall, A. (1972): J. Neurol. Neurosurg. Psychiat. 35:720–725.PubMedCrossRefGoogle Scholar
  3. 3.
    Aquilonius, S.-M., Sjostrom, R. (1971): Life Sci. 10:405–414.CrossRefGoogle Scholar
  4. 4.
    Biel, J. H. and Bopp, B. (1974): In: Psychopharmacological Agents, Vol. 3, (Ed.) M. Gordon, Academic Press, New York, pp.283–333.Google Scholar
  5. 5.
    Bird, E.D. and Iversen, L. L. (1974): Brain 97:457–472.PubMedCrossRefGoogle Scholar
  6. 6.
    Bogdanski, D.F., Salser, F. and Brodie, B. B. (1961): J. Pharmacol. Exp. Ther. 132:176–182.Google Scholar
  7. 7.
    Bowers, M.B., Goodman, E. and Sim, U.M. (1964): J. Nerv. Ment. Dis. 138:383–389.PubMedCrossRefGoogle Scholar
  8. 8.
    Buxton, M. (1976): Comp. Psychiat.17:325–333.CrossRefGoogle Scholar
  9. 9.
    Carlson, A. (1970): In: L-Dopa and Parkinsonism, (Eds.) A. Barbeau, R.H. McDowell, Davis, Philadelphia, pp. 205–213.Google Scholar
  10. 10.
    Carroll, B.J., Frazer, A., Schless, A. and Mendels, J. (1973): Lancet. 1:427–428.PubMedCrossRefGoogle Scholar
  11. 11.
    Casey, D.E. (1976): New Eng. J. Med. 259:1078.Google Scholar
  12. 12.
    Cohen, E.L. and Wurtman, R.J. (1975): Life Sci. 16:1095–1102.PubMedCrossRefGoogle Scholar
  13. 13.
    Cohen, E.L. and Wurtman, R.J. (1976): Science 191:561–562.PubMedCrossRefGoogle Scholar
  14. 14.
    Cools, A.R., Struyker-Boudier, H.A.J. and VanRossum, J. M. (1976): Eur. J. Pharmacol. 37:283–293.PubMedCrossRefGoogle Scholar
  15. 15.
    Davis, K. L., Hollister, L. E., Barchas, J. D. and Berger, P.A. (1976): Life Sci. 19:1507–1516.PubMedCrossRefGoogle Scholar
  16. 16.
    Davis, K. L., Hollister, L. E., Berger, P.A. and Barchas, J. D. (1975): Psychopharmacol. Commun. 1:533–543.PubMedGoogle Scholar
  17. 17.
    Davis, K. L., Hollister, L.E., Goodwin, F.K. and Gordon, E.K. Science (submitted).Google Scholar
  18. 18.
    Davis, K. L., Hollister, L. E., Overall, J., Johnson, A. and Train, K. (1976): Psychopharmacology 51:23–27.PubMedCrossRefGoogle Scholar
  19. 19.
    Domino, E. (personal communication).Google Scholar
  20. 20.
    Enna, S. J., Bird, E.D., Bennet, J. P., Bylund, D. B., Yamamura, H.I., Iversen, L. L. and Snyder, S. H. (1976): New Eng. J.Med. 294:1305–1309.PubMedCrossRefGoogle Scholar
  21. 21.
    Enna, S. J., Stern, L. Z., Wastec, G.J. and Yamamura, H.I. Life Sci. (in press).Google Scholar
  22. 22.
    Fahn, S., Mishkin, M.M. and Hoffman, R.R. (1972): In: Advances in Neurology, I: Huntington’s Chorea 1872–1972, (Eds.) A. Barbeau, T.N. Chase and G.W. Paulson, Raven Press, New York, pp. 581–599.Google Scholar
  23. 23.
    Feighner, J. P., Robins, R., Guze, S. B., Woodruff, R.A., Winokur, G. and Munoz, R. (1972): Arch. Gen. Psychiat. 26:57–63.PubMedCrossRefGoogle Scholar
  24. 24.
    Freeman, J.J. and Jenden, D.J. (1976): Life Sci. 19:949–962.PubMedCrossRefGoogle Scholar
  25. 25.
    Gerlach, J. (1975): Psychopharmacologia 45:51–54.CrossRefGoogle Scholar
  26. 26.
    Gerlach, J., Reisby, N. and Randrup, A. (1974): Psychopharmacologia 34:21–35.PubMedCrossRefGoogle Scholar
  27. 27.
    Gershon, S. and Shaw, F.H. (1961): Lancet 1:1371–1374.PubMedCrossRefGoogle Scholar
  28. 28.
    Goodwin, F.K., Ebert, M.H. and Bunney, W. E. (1972): In: Psychiatric Complications of Medical Drugs, (Ed.) R. I. Shader, Raven Press, New York, pp. 73–101.Google Scholar
  29. 29.
    Growdon, J.H., Cohen, E.L. and Wurtman, R.J. (1977): J. Neurochem. 28:229–232.PubMedCrossRefGoogle Scholar
  30. 30.
    Haubrich, D.R., Wang, P.F.L. and Wedeking, P.W. (1974): Fed. Proe. 33:1503.Google Scholar
  31. 31.
    Haubrich, D.R., Wang, P.F.L. and Clody, D.E. (1975): Life Sci. 17:975–980.PubMedCrossRefGoogle Scholar
  32. 32.
    Hiley, R. C. and Bird, E.D. (1974): Brain Res. 80:355–358.PubMedCrossRefGoogle Scholar
  33. 33.
    Janowsky, D. (personal communication)Google Scholar
  34. 34.
    Janowsky, D.S., El-Yousef, M.K., Davis, J.M. and Serkerke, H. J. (1972): Lancet 2:632–635.PubMedCrossRefGoogle Scholar
  35. 35.
    Janowsky, D., El-Yousef, M.K. and Davis, J.M. (1973): Arch. Gen. Psychiat. 28:542–547.PubMedCrossRefGoogle Scholar
  36. 36.
    Jenden, D.J., Roch, M. and Booth, R. A. (1973): Anal. Biochem. 55:438–448.PubMedCrossRefGoogle Scholar
  37. 37.
    Karczmar, A. G., Scudder, C.L. and Richardson, D. (1973): Neurosci. Res. Prog. Bull. 5:159–244.Google Scholar
  38. 38.
    Klawans, H. L. (1973): Amer. J. Psychiat. 130:82–86.PubMedGoogle Scholar
  39. 39.
    Klawans, H. L. and Rubovits, R. (1972): J. Neural. Transm. 33:235–246.PubMedCrossRefGoogle Scholar
  40. 40.
    Klawans, H. L. and Rubovits, R. (1972): Neurology (Minneap.) 22:107–116.CrossRefGoogle Scholar
  41. 41.
    Klawans, H. L. and Rubovits, R. (1974): J. Neurol. Neurosurg. Psychiat. 27:941–947.CrossRefGoogle Scholar
  42. 42.
    MacKiewicz, J. and Gershon, S. (1964): J. Neuropsychiat. 5:159–169.PubMedGoogle Scholar
  43. 43.
    McGeer, P. L., McGeer, E.G. and Fibiger, H. S. (1973): Neurology (Minneap.) 23:912–917.CrossRefGoogle Scholar
  44. 44.
    Pakkenberg, H., Fog, R. and Nilakantan, B. (1973): Psychopharmacologia 29:329–336.PubMedCrossRefGoogle Scholar
  45. 45.
    Petterson, U., Fryo, G. and Sedvall, G. (1973): Acta Psychiat. Scand. 49:248–256.PubMedCrossRefGoogle Scholar
  46. 46.
    Popova, E.N. (1967): J. Hirnforsch. 9:71–89.PubMedGoogle Scholar
  47. 47.
    Romasenko, V. A. and Jacobson, I. S. (1968): Acta Neuropath. (Berlin) 12:23–32.CrossRefGoogle Scholar
  48. 48.
    Rowntree, D.W., Nevin, S. and Wilson, A. (1950): J. Neurol. Neurosurg. Psychiat. 13:47–59.PubMedCrossRefGoogle Scholar
  49. 49.
    Schelkunov, E.L. (1967): Nature 214:1210–1212.PubMedCrossRefGoogle Scholar
  50. 50.
    Stahl, W. L. and Swanson, P.D. (1974): Neurology (Minneap.) 24:813–819.CrossRefGoogle Scholar
  51. 51.
    Tamminga, C., Smith, R. C., Chang, S., Harasti, J. S. and Davis, J.M. (1976): Lancet 2:905.PubMedCrossRefGoogle Scholar
  52. 52.
    Tarsy, D. and Baldessarini, R. J. (1973): Nature (New Biol.) 245:262–263.Google Scholar
  53. 53.
    Tarsy, D. and Baldessarini, R. J. (1974): Neuropharmacology 13:927–940.PubMedCrossRefGoogle Scholar
  54. 54.
    Tarsy, D., Leopold, N. and Sax, D. S. (1974): Neurology 24:28–33.PubMedCrossRefGoogle Scholar
  55. 55.
    Ulus, I.H. and Wurtman, R.J. (1976): Science 194:1060.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • K. L. Davis
    • 1
    • 2
  • P. A. Berger
    • 1
    • 2
  • L. E. Hollister
    • 1
    • 2
  • J. R. DoAmaral
    • 2
  • J. D. Barchas
    • 2
  1. 1.Veterans Administration HospitalPalo AltoUSA
  2. 2.Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA

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