Plasma Choline in Healthy Subjects and in Huntington’s Chorea Patients on High Oral Doses of Choline Chloride

  • S.-A. Eckernas
  • S.-M. Aquilonius
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


Reports from different laboratories (12, 13, 18–20) that increased plasma concentrations of choline (Ch) in animals are accompanied by increased levels of Ch and ACh in neuronal tissue have created a renewed interest in the regulation of plasma Ch concentration in man. Our earlier knowledge originated mainly from the studies of Bligh (10, 11), who suggested that little variation in the level of plasma Ch occurs under normal and pathological conditions. However, it was recently demonstrated that marked increases in plasma Ch occurred in patients receiving oral supplements of Ch (3, 4, 14, 18) and a plasma Ch concentration about twice that of normal persons was reported in azotemic subjects before hemodialysis (26).


Choline Chloride Increase Plasma Concentration High Oral Dose Choline Concentration Choreatic Movement 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • S.-A. Eckernas
    • 1
  • S.-M. Aquilonius
    • 1
  1. 1.Department of NeurologyUniversity HospitalUppsalaSweden

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