Central Cholinergic Dysfunctions in Man: Clinical Manifestations and Approaches to Diagnosis and Treatment

  • J. Schuberth
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


During the last two decades the different roles of central neurotransmitters in controlling mental functions have been key issues in neuroscience. The identification of acetylcholine (ACh) in brain tissue by Stedman and Sted-man (81) 40 years ago and the finding of Richter and Crossland (70) that the level of brain ACh varies inversely with the state of consciousness in experimental animals became two milestones in elucidating the central effects of this transmitter. During the last few years there has been a rapidly growing interest in applying to clinical practice the now large body of animal data. In this overview our current knowledge, with respect to clinical manifestations of cholinergic dysfunctions will be presented. Some techniques, which have been used as diagnostic tools in this context and as pharmacological means to treat these dysfunctions, will also be discussed.


Tardive Dyskinesia Cholinergic System Mental Symptom Cholinergic Mechanism Cholinergic Dysfunction 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. Schuberth
    • 1
  1. 1.Psychiatric Research Center, Ulleraker HospitalUniversity of UppsalaUppsalaSweden

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