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Central Cholinergic Dysfunctions in Man: Clinical Manifestations and Approaches to Diagnosis and Treatment

  • Chapter
Cholinergic Mechanisms and Psychopharmacology

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 24))

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Abstract

During the last two decades the different roles of central neurotransmitters in controlling mental functions have been key issues in neuroscience. The identification of acetylcholine (ACh) in brain tissue by Stedman and Sted-man (81) 40 years ago and the finding of Richter and Crossland (70) that the level of brain ACh varies inversely with the state of consciousness in experimental animals became two milestones in elucidating the central effects of this transmitter. During the last few years there has been a rapidly growing interest in applying to clinical practice the now large body of animal data. In this overview our current knowledge, with respect to clinical manifestations of cholinergic dysfunctions will be presented. Some techniques, which have been used as diagnostic tools in this context and as pharmacological means to treat these dysfunctions, will also be discussed.

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Authors and Affiliations

  1. Psychiatric Research Center, Ulleraker Hospital, University of Uppsala, S-750 17, Uppsala, Sweden

    J. Schuberth

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  1. J. Schuberth
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  1. University of California School of Medicine, Los Angeles, California, USA

    Donald J. Jenden

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© 1978 Plenum Press, New York

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Schuberth, J. (1978). Central Cholinergic Dysfunctions in Man: Clinical Manifestations and Approaches to Diagnosis and Treatment. In: Jenden, D.J. (eds) Cholinergic Mechanisms and Psychopharmacology. Advances in Behavioral Biology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3096-7_50

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  • DOI: https://doi.org/10.1007/978-1-4684-3096-7_50

  • Publisher Name: Springer, Boston, MA

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