Advertisement

Are There Two Forms of Nicotinic Acetylcholine Receptor?

  • T. Mittag
  • T. Massa
  • S. Gross
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)

Abstract

The purified nicotinic acetylcholine receptor (AChR) is currently being intensively studied to elucidate the molecular events involved in transduction and amplification of ACh binding into a rise in ion permeability. For these purposes AChR from the richest source, the electric organs from Torpedo or Electrophorus, have been used. Progress in this area has been described in several recent reviews. Although mammalian muscle is quantitatively a much less suitable source for AChR, it has provided important information on the dynamics of the receptor molecule (localization, synthesis and degradation) and information on the autoimmune aspects of Myasthenia Gravis (V. Lennon, this volume).

Keywords

Nicotinic Acetylcholine Receptor Toxin Binding Myasthenic Patient Thymus Extract Label Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Almon, R.R., Andrew, C. G. and Appel, S. H. (1974): Biochemistry 13:5522–5528.PubMedCrossRefGoogle Scholar
  2. 2.
    Almon, R.R., Andrew, C. G. and Appel, S.H. (1974): Science 186:55–57.PubMedCrossRefGoogle Scholar
  3. 3.
    Almon, R.R. and Appel, S.H. (1976): Biochemistry 17:3662–3667.CrossRefGoogle Scholar
  4. 4.
    Almon, R.R. and Appel, S. H. (1976): J. Neurochem. 27:1513–1519.PubMedCrossRefGoogle Scholar
  5. 5.
    Brockes, J. P. and Hall, Z.W. (1975): Biochemistry 14:2092–2099.PubMedCrossRefGoogle Scholar
  6. 6.
    Brockes, J. P. and Hall, Z.W. (1975): Biochemistry 14:2100–2106.PubMedCrossRefGoogle Scholar
  7. 7.
    Capra, J.D., Wasserman, R. L. and Kehoe, J. M. (1973): J. Exp. Med. 138:410–427.PubMedCrossRefGoogle Scholar
  8. 8.
    Chiu, T.H., Dolly, J. O. and Barnard, E.A. (1973): Biochem. Biophys. Res. Commun. 51:205–209.PubMedCrossRefGoogle Scholar
  9. 9.
    David, G. S. (1972): Biochem. Biophys. Res. Commun. 48:464–471.PubMedCrossRefGoogle Scholar
  10. 10.
    Dolly, J.O. and Barnard, E.A. (1974): FEBS Letts. 46:145–148.CrossRefGoogle Scholar
  11. 11.
    Lee, C.Y., Chang, S. L. and Kan, S. T. (1972): J. Chromatogr. 72:71–82.PubMedCrossRefGoogle Scholar
  12. 12.
    Lindstrom, J. (1977): Clin. Imm. Immunopath. 7:36–43.CrossRefGoogle Scholar
  13. 13.
    Mittag, T., Kornfeld, P., Tormay, A. and Woo, C. (1976): N. Eng. J. Med. 294:691–694.CrossRefGoogle Scholar
  14. 14.
    Proceedings of the National Computer Conference and Exposition, May, 1974, AFIPS Press, Montvale, New Jersey, pp. 457–483.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • T. Mittag
    • 1
  • T. Massa
    • 1
  • S. Gross
    • 1
  1. 1.Department of Pharmacology, Mt. Sinai School of MedicineCity University of New YorkNew YorkUSA

Personalised recommendations