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The Uptake of Acetylpyrrolidinecholine — A False Cholinergic Transmitter — Into Mammalian Cerebral Cortical Synaptic Vesicles

  • I. von Schwarzenfeld
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)

Abstract

It is now well established that cholinergic vesicles are metabolically heterogeneous organelles. It is, however, still under discussion whether this is due to an intravesicular or an intervesicular heterogeneity. March-banks and Israel (10), supporting the hypothesis of intravesicular heterogeneity, suggested that newly formed ACh is only loosely bound to the vesicles. On the other hand, a distinct vesicle fraction obtained from the electromotor system of Torpedo marmorata after its incubation with radioisotopes shows a high specific radioactivity (12), results which favor the view that intervesicular differences do exist. Biochemical and morphological findings suggest that these vesicles have already passed through an exoendocytotic cycle. If one assumes that these vesicles are located near the presynaptic membrane, the probability that they take up newly formed ACh and release it during stimulation would be higher than that of vesicles further away.

Keywords

Synaptic Vesicle Subcellular Fraction Presynaptic Membrane Synaptosomal Membrane Intraventricular Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • I. von Schwarzenfeld
    • 1
  1. 1.Department of PharmacologyUniversity of MainzMainzGermany

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