Effect of Atropine on Acetylcholine Metabolism in the Mouse Brain

  • B. Karlen
  • G. Lundgren
  • T. Miyata
  • J. Lundin
  • B. Holmstedt
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)

Abstract

Studies on different ways of killing animals have demonstrated that their brain concentrations of ACh and choline (Ch) are very sensitive to postmortem changes (9). When spinal dislocation is employed for this purpose we have found concentrations of ACh and Ch in whole brain of mice of about 16 and 60 nmol/g, respectively (5). When focussed microwave irradiation is used to kill the animals, levels of about 25 and 35 nmol/g are found instead.

Keywords

Microwave Iodide Choline Acetylcholine Deuterium 

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • B. Karlen
    • 1
    • 2
  • G. Lundgren
    • 1
    • 2
  • T. Miyata
    • 1
    • 2
  • J. Lundin
    • 1
    • 2
  • B. Holmstedt
    • 1
    • 2
  1. 1.Department of Toxicology, Swedish Medical Research CouncilKarolinska Institute, FackStockholmSweden
  2. 2.Division of Pharmacy, Department of DrugsNational Board of Health and WelfareUppsalaSweden

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