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Effect of Atropine on Acetylcholine Metabolism in the Mouse Brain

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Cholinergic Mechanisms and Psychopharmacology

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 24))

Abstract

Studies on different ways of killing animals have demonstrated that their brain concentrations of ACh and choline (Ch) are very sensitive to postmortem changes (9). When spinal dislocation is employed for this purpose we have found concentrations of ACh and Ch in whole brain of mice of about 16 and 60 nmol/g, respectively (5). When focussed microwave irradiation is used to kill the animals, levels of about 25 and 35 nmol/g are found instead.

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References

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Author notes

  1. T. Miyata

    Present address: Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University, 1-5 de Honhachi, Kumamoto, Japan

Authors and Affiliations

  1. Department of Toxicology, Swedish Medical Research Council, Karolinska Institute, Fack, S-104 01, Stockholm, Sweden

    B. Karlen, G. Lundgren, T. Miyata, J. Lundin & B. Holmstedt

  2. Division of Pharmacy, Department of Drugs, National Board of Health and Welfare, Box 607, S-751 25, Uppsala, Sweden

    B. Karlen, G. Lundgren, T. Miyata, J. Lundin & B. Holmstedt

Authors
  1. B. Karlen
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  2. G. Lundgren
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  3. T. Miyata
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  4. J. Lundin
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  5. B. Holmstedt
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Editor information

Editors and Affiliations

  1. University of California School of Medicine, Los Angeles, California, USA

    Donald J. Jenden

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© 1978 Plenum Press, New York

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Karlen, B., Lundgren, G., Miyata, T., Lundin, J., Holmstedt, B. (1978). Effect of Atropine on Acetylcholine Metabolism in the Mouse Brain. In: Jenden, D.J. (eds) Cholinergic Mechanisms and Psychopharmacology. Advances in Behavioral Biology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3096-7_45

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  • DOI: https://doi.org/10.1007/978-1-4684-3096-7_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3098-1

  • Online ISBN: 978-1-4684-3096-7

  • eBook Packages: Springer Book Archive

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