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Pharmacological Evidence for a Serotoninergic-Cholinergic Link in the Striatum

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Book cover Cholinergic Mechanisms and Psychopharmacology

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 24))

Abstract

A growing bulk of evidence exists on the presence of various functional links in the central nervous system between different putative neurotransmitters. It is now well established that dopaminergic neurons modulate cholinergic activity in the striatum. Blockade of dopamine receptors by chlorpromazine and haloperidol enchances ACh release (35) and decreases the striatal ACh content (4, 14, 34, and others), while apomorphine and piribedil, dopamine receptor agonists, have the opposite effect (5, 14, 19, 34, and others). Recently, serotoninergic modulation of cholinergic activity in the striatum has also been reported, although some controversy exists as to whether the serotoninergic neurons exert excitatory (3) or inhibitory (17) activity on cholinergic neurons.

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Authors and Affiliations

  1. Institue of Pharmacological Research, Mario Negri Institute, 62 Via Eritrea, Milan, Italy, 20157

    H. Ladinsky, S. Consolo, G. Peri, V. Crunelli & R. Samanin

Authors
  1. H. Ladinsky
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  2. S. Consolo
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  3. G. Peri
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  4. V. Crunelli
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  5. R. Samanin
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Editor information

Editors and Affiliations

  1. University of California School of Medicine, Los Angeles, California, USA

    Donald J. Jenden

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© 1978 Plenum Press, New York

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Ladinsky, H., Consolo, S., Peri, G., Crunelli, V., Samanin, R. (1978). Pharmacological Evidence for a Serotoninergic-Cholinergic Link in the Striatum. In: Jenden, D.J. (eds) Cholinergic Mechanisms and Psychopharmacology. Advances in Behavioral Biology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3096-7_43

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  • DOI: https://doi.org/10.1007/978-1-4684-3096-7_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3098-1

  • Online ISBN: 978-1-4684-3096-7

  • eBook Packages: Springer Book Archive

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