Pharmacological Evidence for a Serotoninergic-Cholinergic Link in the Striatum

  • H. Ladinsky
  • S. Consolo
  • G. Peri
  • V. Crunelli
  • R. Samanin
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


A growing bulk of evidence exists on the presence of various functional links in the central nervous system between different putative neurotransmitters. It is now well established that dopaminergic neurons modulate cholinergic activity in the striatum. Blockade of dopamine receptors by chlorpromazine and haloperidol enchances ACh release (35) and decreases the striatal ACh content (4, 14, 34, and others), while apomorphine and piribedil, dopamine receptor agonists, have the opposite effect (5, 14, 19, 34, and others). Recently, serotoninergic modulation of cholinergic activity in the striatum has also been reported, although some controversy exists as to whether the serotoninergic neurons exert excitatory (3) or inhibitory (17) activity on cholinergic neurons.


Cholinergic Neuron Raphe Nucleus Dorsal Raphe Dorsal Raphe Nucleus Cholinergic Activity 


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • H. Ladinsky
    • 1
  • S. Consolo
    • 1
  • G. Peri
    • 1
  • V. Crunelli
    • 1
  • R. Samanin
    • 1
  1. 1.Institue of Pharmacological ResearchMario Negri InstituteMilanItaly

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