Presynaptic Modulation by Norepinephrine and Dopamine of Acetylcholine Release in the Peripheral and Central Nervous System

  • E. S. Vizi
  • A. Ronai
  • L. G. HarsingJr.
  • J. Knoll
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


Discussion on the mode of action of psychoactive drugs are often based on the changes in brain monoamine content, although any change in content induced by a drug is not necessarily the best indicator of its mechanism of action. Electrophysiological methods, by which the receptors of central neuron for biogenic amines may be characterized as to location and function, still fail to provide convincing evidence of the mode of action of biogenic amines. With these techniques the most commonly observed action of norepinephrine (NE) in most parts of the central nervous system is depression of firing (7, 27–29). Although the typical actions of neurotransmitters on cell excitability in most regions of the neural axis have been described, relatively less information is available on the underlying mechanisms. In the last few years, however, neurochemical evidence has also been obtained concerning the pre- and post-synaptic action of different neurotransmitters in the CNS.


Nerve Terminal Biogenic Amine Field Stimulation Presynaptic Inhibition Paralytic Ileus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • E. S. Vizi
    • 1
  • A. Ronai
    • 1
  • L. G. HarsingJr.
    • 1
  • J. Knoll
    • 1
  1. 1.Department of PharmacologySemmelweis University of MedicineBudapestHungary

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