Effects of Polypeptide Neurotoxins on Acetylcholine Storage and Release

  • B. Howard
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


There are several polypeptide neurotoxins that act on nerve terminals to alter the storage and release of neurotransmitters. Electrophysiological studies have shown that these neurotoxins produce a wide variety of effects on the metabolism of transmitters. For the most part, their molecular mechanisms of action are not understood. However, I believe enough is presently known to indicate that if we could learn the biochemical details of the activities of these toxins, we would know much of the biochemical mechanisms by which transmitters are stored and released. Furthermore, I suggest that enough is already understood about these toxins to indicate that the storage and release of transmitters occur by processes that are biochemically much more complicated and that involve many more molecular factors than has previously been appreciated. The following is a discussion of how these toxins affect the storage and release of transmitters.


Botulinum Toxin Synaptic Vesicle Nerve Terminal Neuromuscular Junction Neuromuscular Blockade 
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© Plenum Press, New York 1978

Authors and Affiliations

  • B. Howard
    • 1
  1. 1.Department of Biological Chemistry, School of MedicineUniversity of CaliforniaLos AngelesUSA

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