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Effects of Polypeptide Neurotoxins on Acetylcholine Storage and Release

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Cholinergic Mechanisms and Psychopharmacology

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 24))

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Abstract

There are several polypeptide neurotoxins that act on nerve terminals to alter the storage and release of neurotransmitters. Electrophysiological studies have shown that these neurotoxins produce a wide variety of effects on the metabolism of transmitters. For the most part, their molecular mechanisms of action are not understood. However, I believe enough is presently known to indicate that if we could learn the biochemical details of the activities of these toxins, we would know much of the biochemical mechanisms by which transmitters are stored and released. Furthermore, I suggest that enough is already understood about these toxins to indicate that the storage and release of transmitters occur by processes that are biochemically much more complicated and that involve many more molecular factors than has previously been appreciated. The following is a discussion of how these toxins affect the storage and release of transmitters.

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  1. Department of Biological Chemistry, School of Medicine, University of California, Los Angeles, California, 90024, USA

    B. Howard

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  1. University of California School of Medicine, Los Angeles, California, USA

    Donald J. Jenden

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Howard, B. (1978). Effects of Polypeptide Neurotoxins on Acetylcholine Storage and Release. In: Jenden, D.J. (eds) Cholinergic Mechanisms and Psychopharmacology. Advances in Behavioral Biology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3096-7_40

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