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Cholinergic Mechanisms and Psychopharmacology pp 551–563Cite as

Endogenous Modulators of Acetylcholine Turnover Rate

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 24))

Abstract

Measurements of ACh turnover rates (TRA Ch) in specific rat brain areas containing small, intrinsic cholinergic neurons or long axon cholinergic projections are of value in under standing the functional participation of a specific group of cholinergic neurons during behavioral activities or in the mode of action of drugs. The basis for this inference is the hypothesis that ACh synthesis increases or decreases proportionally to the increase or decrease of neuronal activity. This hypothesis is in part supported by the demonstration that the value of TRA Ch in the resting superior cervical ganglion never exceeds 20% of the maximum rate that can be attained during electrical stimulation of preganglionic nerves (33).

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Author information

Authors and Affiliations

  1. Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D. C., 20032, USA

    D. L. Cheney, F. Moroni, D. Malthe-Sørenssen & E. Costa

Authors
  1. D. L. Cheney
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  2. F. Moroni
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  3. D. Malthe-Sørenssen
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  4. E. Costa
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Editor information

Editors and Affiliations

  1. University of California School of Medicine, Los Angeles, California, USA

    Donald J. Jenden

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© 1978 Plenum Press, New York

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Cheney, D.L., Moroni, F., Malthe-Sørenssen, D., Costa, E. (1978). Endogenous Modulators of Acetylcholine Turnover Rate. In: Jenden, D.J. (eds) Cholinergic Mechanisms and Psychopharmacology. Advances in Behavioral Biology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3096-7_39

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  • DOI: https://doi.org/10.1007/978-1-4684-3096-7_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3098-1

  • Online ISBN: 978-1-4684-3096-7

  • eBook Packages: Springer Book Archive

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