Endogenous Modulators of Acetylcholine Turnover Rate

  • D. L. Cheney
  • F. Moroni
  • D. Malthe-Sørenssen
  • E. Costa
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


Measurements of ACh turnover rates (TRA Ch) in specific rat brain areas containing small, intrinsic cholinergic neurons or long axon cholinergic projections are of value in under standing the functional participation of a specific group of cholinergic neurons during behavioral activities or in the mode of action of drugs. The basis for this inference is the hypothesis that ACh synthesis increases or decreases proportionally to the increase or decrease of neuronal activity. This hypothesis is in part supported by the demonstration that the value of TRA Ch in the resting superior cervical ganglion never exceeds 20% of the maximum rate that can be attained during electrical stimulation of preganglionic nerves (33).


Tardive Dyskinesia Cholinergic Neuron Gaba Receptor Opiate Receptor Brain Nucleus 
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  1. 1.
    Anden, N.-E. and Bedard, P. (1971): J. Pharm. Pharmacol. 23: 460–462.PubMedCrossRefGoogle Scholar
  2. 2.
    Anden, N.-E., Rubenson, A., Fuxe, K. and Hokfelt, T. (1967): J. Pharm. Pharmacol. 19:627–629.PubMedCrossRefGoogle Scholar
  3. 3.
    Bloom, F., Battenberg, E., Rossier, J., Ling, N., Leppaluoto, J., Vargo, T.M. and Guillemin, R. (1977): Life Sci. 20:43–48.PubMedCrossRefGoogle Scholar
  4. 4.
    Bloom, F., Costa, G. and Salmoiraghi, G. C. (1965): J. Pharmacol. Exp. Ther. 150:244–252.PubMedGoogle Scholar
  5. 5.
    Bloom, F., Segal, D., Ling, N. and Guillemin, R. (1976): Science 194:630–632.PubMedCrossRefGoogle Scholar
  6. 6.
    Brownstein, M., Arimura, A., Sato, H., Schally, A.V. and Fine, J. S. (1975): Endocrinology 96:1456–1461.PubMedCrossRefGoogle Scholar
  7. 7.
    Butcher, S.G. and Butcher, L. L. (1974): Brain Res. 71:167–171.PubMedCrossRefGoogle Scholar
  8. 8.
    Carino, M.A., Smith, J.R., Weick, B.G. and Horita, A. (1977): Life Sci. 19:1687–1692.CrossRefGoogle Scholar
  9. 9.
    Carlsson, A. (1959): Pharmacol. Rev. 11:490–493.PubMedGoogle Scholar
  10. 10.
    Cheney, D.L., LeFevre, H. F. and Racagni, G. (1975): Neuropharmacology 14:801–809.PubMedCrossRefGoogle Scholar
  11. 11.
    Connor, J.D. (1968): Science 160:899–900.PubMedCrossRefGoogle Scholar
  12. 12.
    Costa, E. and Groppetti, A. (1970): In: Amphetamines and Related Compounds, (Eds.) E. Costa and S. Garattini, Raven Press, New York, pp.231–255.Google Scholar
  13. 13.
    Costa, E., Guidotti, A., Mao, C. C. and Suria, A. (1975): Life Sci. 17:167–186.PubMedCrossRefGoogle Scholar
  14. 14.
    Curtis, D.R. and Johnston, G.A.R. (1974): Ergebn. Physiol. 69: 97–188.PubMedGoogle Scholar
  15. 15.
    Eccles, J. C. (Ed.)(1973): The Understanding of the Brain, McGraw Hill Publ. Co., New York.Google Scholar
  16. 16.
    Elde, R., Hokfelt, T., Johansson, O. and Terenius, L. (1976): Neuroscience 1:349–351.PubMedCrossRefGoogle Scholar
  17. 17.
    Gnegy, M. E., Uzunov, P. and Costa, E. (1977): J. Pharmacol. Exp. Ther. (in press).Google Scholar
  18. 18.
    Goldstein, A. (1976): Science 193:1081–1086.PubMedCrossRefGoogle Scholar
  19. 19.
    Guidotti, A., Cheney, D. L., Trabucchi, M., Doteuchi, M., Wang, C. and Hawkins, R.A. (1974): Neuropharmacology 13:1115–1122.PubMedCrossRefGoogle Scholar
  20. 20.
    Hokfelt, T., Fuxe, K., Johansson, O., Jeffcoate, S. and White, N. (1976): Eur. J. Pharmacol. 31:389–392.Google Scholar
  21. 21.
    Hokfelt, T., Meyerson, B., Nilsson, G., Pernow, B. and Sacks, C. (1975): Brain Res. 104:181–186.CrossRefGoogle Scholar
  22. 22.
    Hong, J. S., Costa, E. and Yang, H.-Y. T. (1976); Brain Res. 118: 523–525.PubMedCrossRefGoogle Scholar
  23. 23.
    Hong, J.S., Yang, H.-Y. T., Racagni, G. and Costa, E. (1977): Brain Res. 122:541–544.PubMedCrossRefGoogle Scholar
  24. 24.
    Ito, M. (1976): In: GABA in Nervous System Function, (Eds.) E. Roberts, T. N. Chase and D. B. Tower, Raven Press, New York, pp.427–448.Google Scholar
  25. 25.
    Iversen, L. L. and Bloom, F. E. (1972): Brain Res. 41:131–143.PubMedCrossRefGoogle Scholar
  26. 26.
    Jacobowitz, D.M. and Palkovits, M. (1974): J. Comp. Neurol. 157:13–28.PubMedCrossRefGoogle Scholar
  27. 27.
    Johnston, G.A.R., Curtis, D.R., DeGroat, W. C. and Duggan, A. W. (1968): Biochem. Pharmacol. 17:2488–2489.PubMedCrossRefGoogle Scholar
  28. 28.
    Kanazawa, I., Emson, P.C. and Cuello, A.C. (1977): Brain Res. 119:447–453.PubMedCrossRefGoogle Scholar
  29. 29.
    Klawans, H. L. Jr. (1973): Amer. J. Psychiat. 130:82–86.PubMedGoogle Scholar
  30. 30.
    Krogsgaard-Larsen, P., Johnston, G.A.R., Curtis, D.R., Game, C.J.A. and McCulloch, R.M. (1975): J. Neurochem. 25:803–809.PubMedCrossRefGoogle Scholar
  31. 31.
    Krulich, L., Illner, P., Fawcett, C. P., Quijada, M. and McCann, S.M. (1972): In: Growth and Growth Hormone, (Eds.) A. Pecile and E. E. Muller, Int. Congr. Ser. No. 244, Exerpta Medica, Amsterdam, pp. 306–316.Google Scholar
  32. 32.
    Lewis, P.R. and Shute, C. C.D. (1967): Brain 90:521–540.PubMedCrossRefGoogle Scholar
  33. 33.
    MacIntosh, F. C. (1963): Canad. J. Biochem. Physiol. 41:2555–2571.CrossRefGoogle Scholar
  34. 34.
    McGeer, E.G. and McGeer, P. L. (1976): Nature 263:517–518.PubMedCrossRefGoogle Scholar
  35. 35.
    Meek, J.L., Yang, H.-Y. T. and Costa, E. (1977): Neuropharmacology (in press).Google Scholar
  36. 36.
    Moroni, F., Cheney, D.L. and Costa, E. (1977): Nature (in press).Google Scholar
  37. 37.
    Naik, S.R., Guidotti, A. and Costa, E. (1976): Neuropharmacology 15:479–484.PubMedCrossRefGoogle Scholar
  38. 38.
    Polc, P., Mohler, H. and Haefely, W. (1974): N.-S. Arch. Pharmacol. 284:319–337.CrossRefGoogle Scholar
  39. 39.
    Bacagni, G., Cheney, D. L., Trabucchi, M. and Costa, E. (1976): J. Pharmacol. Exp. Ther. 196:323–332.Google Scholar
  40. 40.
    Bacagni, G., Cheney, D. L., Trabucchl, M., Wang, C. and Costa, E. (1974): Life Sci. 15:1961–1975.CrossRefGoogle Scholar
  41. 41.
    Bacagni, G., Cheney, D. L., Zsilla, G. and Costa, E. (1976): Neuropharmacology 15:723–736.CrossRefGoogle Scholar
  42. 42.
    Schenker, C., Mroz, E.A. and Leeman, S. E. (1976): Nature 264: 790–792.PubMedCrossRefGoogle Scholar
  43. 43.
    Simantov, B., Kuhar, M. J., Pasternak, G. W. and Snyder, S. H. (1976): Brain Bes. 106:189–197.CrossRefGoogle Scholar
  44. 44.
    Stadler, H., Lloyd, K. G., Gadae-Cira, M. and Bartholini, G. (1973): Brain Bes. 55:476–480.CrossRefGoogle Scholar
  45. 45.
    Stille, G., Lauener, H. and Eichenberger, E. (1971): Il Farmaco 26:603–625.Google Scholar
  46. 46.
    Szentagothai, J., Flerko, B., Mess, B. and Halasz, B. (1968): Akademiai Kiado, Budapest.Google Scholar
  47. 47.
    Trabucchi, M., Cheney, D. L., Bacagni, G. and Costa, E. (1974): Nature 249:664–666.PubMedCrossRefGoogle Scholar
  48. 48.
    Trabucchi, M., Cheney, D. L., Bacagni, G. and Costa, E. (1975): Brain Bes. 85:130–134.CrossRefGoogle Scholar
  49. 49.
    Uhl, G.B. and Snyder, S. H. (1976): Life Sci. 19:1827–1832.PubMedCrossRefGoogle Scholar
  50. 50.
    Yang, H.-Y. T., Hong, J.S. and Costa, E. (1977): Neuropharmacology (in press).Google Scholar
  51. 51.
    Zsilla, G., Cheney, D. L. and Costa, E. (1976): N.-S. Arch. Pharmacol. 294:251–255.CrossRefGoogle Scholar
  52. 52.
    Zsilla, G., Bacagni, G., Cheney, D.L. and Costa, E. (1977): Neuropharmacology 16:25–30.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • D. L. Cheney
    • 1
  • F. Moroni
    • 1
  • D. Malthe-Sørenssen
    • 1
  • E. Costa
    • 1
  1. 1.Laboratory of Preclinical Pharmacology, National Institute of Mental HealthSt. Elizabeths HospitalUSA

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