Factors Affecting Choline Uptake by Ganglia and the Relationship Between Choline Uptake and Acetylcholine Synthesis

  • B. Collier
  • D. Ilson
  • S. Lovat
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


Acetylcholine (ACh) synthesis in cholinergic nerve terminals depends upon their ability to transport choline (Ch) from extracellular sources into the nerve ending cytosol, the site of ACh synthesis (18), for the nerve cannot synthesize Ch (1, 2, 8, 9). There is now considerable evidence that ACh synthesis is supported as the result of activity of a Ch transport mechanism with high affinity for Ch (4, 20, 21, 26, 38).


Transmitter Release Cholinergic Nerve Choline Uptake Acetylcholine Synthesis Cholinergic Nerve Terminal 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • B. Collier
    • 1
  • D. Ilson
    • 1
  • S. Lovat
    • 1
  1. 1.Department of Pharmacology and TherapeuticsMcGill University, McIntyre Medical BuildingMontrealCanada

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