The Source of Choline for Acetylcholine Synthesis

  • G. B. Ansell
  • S. Spanner
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


When the first meeting of the series on Cholinergic Mechanisms was held in Skokloster (1970) few pharmacologists or biochemists working on the cholinergic system had given much thought to the source of Ch for ACh synthesis. Nor had much thought been given to the relationship of the Ch of ACh to that of other compounds in nervous tissue. It would be no exaggeration to say that the study of the ramifications of Ch metabolism is now a minor industry. A recent excellent review on the source of Ch for ACh synthesis has 151 references (26) and investigations now range from the minutiae of Ch transport to the use of Ch therapy in the tardive dyskinesias. This short account will deal only with the central nervous system.


Tardive Dyskinesia Cholinergic Mechanism High Affinity Uptake Acetylcholine Synthesis Cholinergic Terminal 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • G. B. Ansell
    • 1
  • S. Spanner
    • 1
  1. 1.Department of Pharmacology (Preclinical)University of Birmingham Medical SchoolEngland

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