Biochemical Characterization of Muscarinic Cholinergic Receptors in Huntington’s Disease

  • H. I. Yamamura
  • G. J. Wastek
  • P. C. Johnson
  • L. Z. Stern
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


Huntington’s disease (HD) is an autosomal dominantly inherited progressive neurological disorder characterized by involuntary choreiform movements and dementia. Occurring at a frequency of approximately 5 to 10 in 10,000, it manifests itself in two forms (11). The more frequent form is of adult onset and becomes symptomatic in the fourth or fifth decade of life. The early onset form, or Westphal variant, occurs in less than 5% of those individuals with HD and has a rapid course involving rigid, hypokinetic movements frequently accompanied by seizures and severe mental retardation (4).


Caudate Nucleus Hill Coefficient Muscarinic Agonist Muscarinic Cholinergic Receptor Sodium Potassium Phosphate 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • H. I. Yamamura
    • 1
  • G. J. Wastek
    • 1
  • P. C. Johnson
    • 2
  • L. Z. Stern
    • 3
  1. 1.Department of Pharmacology, College of MedicineUniversity of Arizona Health Sciences CenterTucsonUSA
  2. 2.Department of Pathology, College of MedicineUniversity of Arizona Health Sciences CenterTucsonUSA
  3. 3.Department of Neurology, College of MedicineUniversity of Arizona Health Sciences CenterTucsonUSA

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