Biochemical Characterization of Muscarinic Cholinergic Receptors in Huntington’s Disease
Huntington’s disease (HD) is an autosomal dominantly inherited progressive neurological disorder characterized by involuntary choreiform movements and dementia. Occurring at a frequency of approximately 5 to 10 in 10,000, it manifests itself in two forms (11). The more frequent form is of adult onset and becomes symptomatic in the fourth or fifth decade of life. The early onset form, or Westphal variant, occurs in less than 5% of those individuals with HD and has a rapid course involving rigid, hypokinetic movements frequently accompanied by seizures and severe mental retardation (4).
KeywordsCaudate Nucleus Hill Coefficient Muscarinic Agonist Muscarinic Cholinergic Receptor Sodium Potassium Phosphate
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