Abstract
The membrane of chromaffin cells contains nicotinic and muscarinic receptors which are innervated by cholinergic axons — the only neurites reaching the adrenal gland. Persistent activation of nicotinic receptors is associated with an increase in the 3′, 5′-cyclic adenosine monophosphate (cAMP) (19) content of adrenal medulla, whereas the stimulation of muscarinic receptors causes an increase in the 3′, 5′-cyclic guanosine monophosphate (cGMP) content (21). The data reported in Fig. 1 show that carbamylcholine, a mixed agonist of nicotinic and muscarinic receptors increases the cAMP and cGMP content of adrenal medulla. In addition, Fig. 1 shows that hexamethonium blocks the increase of cAMP but not that of cGMP elicited by carbamylcholine, In contrast, atropine blocks the increase in cGMP but not that in cAMP elicited by the cholinergic receptor agonist.
Persistent Activation of Acetylcholine Receptors in Chromaffin Cells and Second Messenger Responses
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Costa, E., Chuang, D.M., Guidotti, A., Hollenbeck, R. (1978). Control of Nuclear Function in Chromaffin Cells by Persistent Activation of Nicotinic Receptors. In: Jenden, D.J. (eds) Cholinergic Mechanisms and Psychopharmacology. Advances in Behavioral Biology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3096-7_20
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