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Correlation Between the Binding Properties and Pharmacological Responses of Muscarinic Receptors

  • N. J. M. Birdsall
  • A. S. V. Burgen
  • E. C. Hulme
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)

Abstract

Until recently our understanding of the nature of how muscarinic drugs act on tissues has been derived from an analysis of the actions of agonists and antagonists on some physiological response such as the contraction of smooth muscle. With the development of methods of measuring directly the binding of drugs to muscarinic receptors, an independent set of data has been obtained which should permit a more detailed understanding of the nature of muscarinic drug action.

Keywords

Muscarinic Receptor Affinity Constant Conformation Change High Affinity Receptor Muscarinic Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Birdsall, N.J.M., Burgen, A.S.V., Hiley, C.R. and Hulme, E.C. (1976): J. Supramolec. Struct. 4:367–371.CrossRefGoogle Scholar
  2. 2.
    Birdsall, N.J. M., Burgen, A.S.V. and Hulme, E.C. (in preparation), 1977.Google Scholar
  3. 3.
    Burgen, A.S.V. and Hiley, C.R. (1975): In: Cholinergic Mechanisms (Ed.) P.G. Waser, Raven Press, New York, pp. 381–385.Google Scholar
  4. 4.
    Hulme, E.C., Burgen, A.S.V. and Birdsall, N.J. M. (1976): In: Proc. INSERM Colloquium on Physiology and Pharmacology of Smooth Muscle, pp. 49–70.Google Scholar
  5. 5.
    Hulme, E.C., Burgen, A.S.V. and Birdsall, N.J. M. (in preparation), 1977.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • N. J. M. Birdsall
    • 1
  • A. S. V. Burgen
    • 1
  • E. C. Hulme
    • 1
  1. 1.Division of Molecular PharmacologyNational Institute for Medical ResearchLondonEngland

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