Comparative Immunochemistry of Mammalian Brain and Eel Electric Tissue Acetylcholinesterases

  • A. J. Trevor
  • A. J. Greenberg
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


Acetylcholinesterase (AChE, EC plays an important role in the control of excitability of nerve and muscle tissue via its hydrolytic inactivation of ACh at postsynaptic sites. However, most studies on purified forms of AChE have concerned the enzymes from electric tissues of marine, non-mammalian species (11). AChE has been purified from mammalian brain tissues (2, 16) and while such preparations appear similar in catalytic function to electric tissue enzymes, differences are apparent with respect to molecular size of the enzyme forms (2) and active site numbers (4).


Bovine Brain Double Diffusion Brain AChE Bovine Erythrocyte Asymmetric Form 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • A. J. Trevor
    • 1
  • A. J. Greenberg
    • 1
  1. 1.Department of Pharmacology, School of MedicineUniversity of CaliforniaSan FranciscoUSA

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