Advertisement

Activation of Choline Acetyltransferase by Chloride: A Possible Regulatory Mechanism

  • J. Rossier
  • P. Benda
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)

Abstract

Numerous mechanisms have already been proposed for the regulation of ACh synthesis by CAT (AcCoA: choline-O-acetyltransferase, EC:2.3. 1.6). They are: regulation by mass action (14, 35); inhibition by ACh (16) and regulation by salts (27). None of these proposed mechanisms seems sufficient to explain the perfect regulation of ACh synthesis in cholinergic nerve terminals (2, 9, 10).

Keywords

Ionic Strength Crude Enzyme Tris Acetate Graphical Determination Physiological Ionic Strength 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Barker, L.A. and Mittag, T.W. (1975): J. Pharmacol. Exp. Ther. 192:86–94.PubMedGoogle Scholar
  2. 2.
    Birks, R.I. and MacIntosh, F. C. (1961): Canad. J. Biochem. Physiol. 39:787–827.CrossRefGoogle Scholar
  3. 3.
    Boyer, P.D. (1971): The Enzymes, Vol.3, 3rd Edition, Academic Press, New York.Google Scholar
  4. 4.
    Cleland, W.W. (1963): Biochim. Biophys. Acta 67:104–137.PubMedCrossRefGoogle Scholar
  5. 5.
    Collier, B. and MacIntosh, F. C. (1969): Canad. J. Physiol. Pharmacol. 47:127–135.CrossRefGoogle Scholar
  6. 6.
    Collier, B., Lovat, S., Ilson, D., Barker, L.A. and Mittage, T.W. (1977): J. Neurochem. (in press).Google Scholar
  7. 7.
    Craine, J.E., Daniels, G. H. and Kaufman, S. (1973): J. Biol. Chem. 248:7838–7844.PubMedGoogle Scholar
  8. 8.
    Douzou, P. and Maurel, P. (1976): C.R. Acad. Sci. Paris 282: 2107–2110.Google Scholar
  9. 9.
    Dowdall, M.J., Fox, G., Wachtler, K., Whittaker, V. P. and Zimmermann, H. (1975): Cold Spring Harbor Symp. Quant. Biol. 40:65–81.CrossRefGoogle Scholar
  10. 10.
    Dunant, Y., Gautron, J., Israel, M., Lesbats, B. and Manaranche, R. (1974): J. Neurochem. 23:635–643.PubMedCrossRefGoogle Scholar
  11. 11.
    Engasser, J. M. and Horvath, C. (1975): Biochem. J. 145:431–435.PubMedGoogle Scholar
  12. 12.
    Fonnum, F. (1968): Biochem. J. 109:389–398.PubMedGoogle Scholar
  13. 13.
    Fonnum, F. (1969): Biochem. J. 115:465–472.PubMedGoogle Scholar
  14. 14.
    Glover, V.A.S. and Potter, L.T. (1971): J. Neurochem. 18: 571–580.PubMedCrossRefGoogle Scholar
  15. 15.
    Israel, M., Lesbats, B., Marsal, J. and Meunier, F.-M.(1975): C. R. Acad. Sci. Paris 280:905–908.Google Scholar
  16. 16.
    Kaita, A.A. and Goldberg, A.M. (1969): J. Neurochem. 16:1185–1191.PubMedCrossRefGoogle Scholar
  17. 17.
    Kuczenski, R., Segal, D.S. and Mandell, A.J. (1975): J. Neurochem. 24:39–45.PubMedCrossRefGoogle Scholar
  18. 18.
    Lefresne, P., Guyenet, P., Beaujouan, J.-C. and Glowinski, J. (1975): J. Neurochem. 25:415–422.PubMedCrossRefGoogle Scholar
  19. 19.
    Lifshitz, R. and Levitski, A. (1976): Biochemistry (Easton) 15: 1987–1993.CrossRefGoogle Scholar
  20. 20.
    MacCaman, R. E. and Hunt, J.M. (1965): J. Neurochem. 12:250–259.Google Scholar
  21. 21.
    MacIlwain, H. (1966): Biochemistry and the Central Nervous System, 3rd Edition, Little, Brown & Co., Boston.Google Scholar
  22. 22.
    Marchbanks, R.M. and Campbell, C.W. B. (1976): J. Neurochem. 26:973–980.PubMedCrossRefGoogle Scholar
  23. 23.
    Marquis, J.K. and Webb, G.D. (1974): Biochem. Pharmacol. 23: 3459–3465.PubMedCrossRefGoogle Scholar
  24. 24.
    Molinoff, P. B. and Kravitz, E.A. (1968): J. Neurochem. 15:391–409.PubMedCrossRefGoogle Scholar
  25. 25.
    Morris, D., Maneckjee, A. and Hebb, C. (1971): Biochem. J. 125: 857–863.PubMedGoogle Scholar
  26. 26.
    Nachmansohn, D. and Machado, A. L. (1943): J. Neurophysiol. 6: 397–403.Google Scholar
  27. 27.
    Potter, L.T., Glover, V.A.S. and Saelens, J.K. (1968): J. Biol. Chem. 243:3864–3870.PubMedGoogle Scholar
  28. 28.
    Prince, A.K. and Hide, E.G.H. (1971): Nature (Lond.) 234:222–223.CrossRefGoogle Scholar
  29. 29.
    Rossier, J. (1976): J. Neurochem. 26:543–548.PubMedCrossRefGoogle Scholar
  30. 30.
    Rossier, J. (1977): Int. Rev. Neurobiol. 20: (in press).Google Scholar
  31. 31.
    Rossier, J. (1977): Biochem. J. (in press).Google Scholar
  32. 32.
    Rossier, J., Bauman, A. and Benda, P. (1973): FEBS Lett. 32: 231–234.PubMedCrossRefGoogle Scholar
  33. 33.
    Schuberth, J. (1966): Biochim. Biophys. Acta 122:470–480.Google Scholar
  34. 34.
    Simon, J. R., Atweh, S. and Kuhar, M.J. (1976): J. Neurochem. 26:909–922.PubMedCrossRefGoogle Scholar
  35. 35.
    White, J.L. and Wu, C. (1973): J. Neurochem. 20:297–307.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. Rossier
    • 1
    • 2
  • P. Benda
    • 3
  1. 1.The Salk Institute for Biological StudiesLa JollaUSA
  2. 2.Charge de RechercheINSERMFrance
  3. 3.Groupe de Neuroendocrinologie Cellulaire, Laboratorie de Physiologie CellulaireCollege de FranceParisFrance

Personalised recommendations