Studies on the Mechanism of Action of Choline Acetyltransferase

  • H. G. Mautner
  • S. F. Currier
Part of the Advances in Behavioral Biology book series (ABBI, volume 24)


Choline acetyltransferase (CAT) is the enzyme responsible for the formation of the essential neurotransmitter ACh by catalyzing the alcoholysis of acetyl CoA (AcCoA). This reaction is favored only slightly thermodynamically under physiological conditions (19), probably because ACh itself is a high-energy compound (12). It is likely that this is the case because the coulombic interaction between the trimethylammonium group and the acyloxy oxygen of this ester (16) favors nucleophilic attack on the carbonyl carbon.


Choline ACETYLTRANSFERASE Thiol Reagent Naphthalene Sulfonate Choline Acetyl Transferase Cibacron Blue F3GA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • H. G. Mautner
    • 1
  • S. F. Currier
    • 1
  1. 1.Department of Biochemistry and PharmacologyTufts University School of MedicineBostonUSA

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