Abstract
Two major sets of requirements must be met to measure accurately the steady state concentrations of high turnover components of the central nervous system: 1) An assay must be available that has suitable sensitivity, specificity and reliability for use on this heterogenous chemical system and 2) a method must be used for the rapid and precise inactivation of synthetic and degradative enzymes related to the components to be studied and the in vivo relationships of these enzymes should be known to interpret the analytical results properly.
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© 1978 Plenum Press, New York
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Stavinoha, W.B., Frazer, J., Modak, A.T. (1978). Microwave Fixation for the Study of Acetylcholine Metabolism. In: Jenden, D.J. (eds) Cholinergic Mechanisms and Psychopharmacology. Advances in Behavioral Biology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3096-7_11
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DOI: https://doi.org/10.1007/978-1-4684-3096-7_11
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