Effects of Chronic Dosage with Chlorpromazine and Gerovital H3 in the Aging Brain

  • T. Samorajski
  • Albert Sun
  • C. Rolsten
Part of the Advances in Behavioral Biology book series (ABBI, volume 23)


Aging may be considered a progressive deterioration of an organism after maturation that leads to physiological decline, increasing incidence of pathological lesions, and death. The rate of aging and duration of life appear to result from an interaction between the genetic program in the cell and influences from the external environment. While the causes of aging are unknown, there is evidence that the rate of aging may be mediated by the brain, especially by the hypothalamus and the closely linked pituitary and peripheral endocrine system (Everitt, 1976). Disproportionate changes in this system may result in “disregulation” of the organism (Frolkis, 1976), or an elevation of hypothalamic threshold to feed back control (Dilman, 1971), which in turn cause the development of age-related pathology.


Pigment Granule Spontaneous Locomotor Activity Procaine Hydrochloride Chronic Dosage Lipofuscin Pigment 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • T. Samorajski
    • 1
  • Albert Sun
    • 2
  • C. Rolsten
    • 1
  1. 1.Neurobiology of Aging SectionTexas Research Institute of Mental SciencesHoustonUSA
  2. 2.Sinclair Comparative Medicine Research FarmUniversity of MissouriColumbiaUSA

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