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Chromatin in Aging Brain

  • F. Marott Sinex
Part of the Advances in Behavioral Biology book series (ABBI, volume 23)

Abstract

Dementia is a major problem for the Veterans Administration and will become more so as the World War I veterans enter their seventies and eighties. Dementia and confusional states may occur for a number of reasons. However, in a large number of cases, perhaps half of those with severe memory loss show a pathology similar to that first described in patients with pre-senile dementia by Alzheimer, namely cortical atrophy, neurofibrillary tangles and senile plaques. For want of a better name, one is tempted to call dementia in the elderly with this type of pathology an Alzheimer’s type senile dementia, even though by definition Alzheimer’s disease is a pre-senile dementia. We may need a better name. Euphanisms cannot hide a problem on which little research is being done, which is costing more and more money, and placing more and more patients in chronic care institutions.

Keywords

Neurofibrillary Tangle Aging Brain Senile Dementia Nonhistone Protein Apurinic Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Absher, P.M., Absher, R.G. and Barnes, W.D. Time lapse cinemicro-photographic studies of cell division patterns of human diploid fibroblasts (WI-38) during their in vitro lifespan. Advan. in Exp. Med. and Biol. 53:91–105, 1975.Google Scholar
  2. Alexander, P. and Connell, D.I. Shortening of the lifespan of mice by irradiation with x-rays and treatment with radiomimetic chemicals. Radiation Res. 12:38–48, 1960.PubMedCrossRefGoogle Scholar
  3. Burnet, Sir MacF. “Intrinsic Mutagenesis: A Genetic Approach to Aging”. Wiley, New York-Toronto, 1974.CrossRefGoogle Scholar
  4. Chamberlin, M. and Berg, P. Deoxyribonucleic acid directed synthesis of ribonucleic acid by an enzyme from Escherichia coli. Proc. Natl. Acad. Sci. USA 48:81–94, 1962.PubMedCrossRefGoogle Scholar
  5. Clemente, C.D. and Holst, E.A. Pathological changes in neurons neuroglia and blood-brain barrier induced by x-irradiation of heads of monkeys. A.M.A. Arch. Neuro. Psych. 71:66–79, 1954.Google Scholar
  6. Cook, P.R. and Brazell, I.A. Detection and repair of single strand breaks in nuclear DNA. Nature 263:679–682, 1976.PubMedCrossRefGoogle Scholar
  7. Crapper, D.R., Kushinan, S.S. and Dalton, A.J. Brain aluminum distribution in mouse liver and brain tissues as a function of age. Trans. Amer. Neurol. Assoc. 98:15–20, 1973.Google Scholar
  8. Cristofalo, V.J. Metabolic aspects to aging in diploid human cells. In: Aging in Cell and Tissue Culture, (Eds. V. J. Cristofalo and E. Holeckova), Plenum Press, New York, pp. 83–120, 1970.CrossRefGoogle Scholar
  9. Curtis, H., Jr. “Biological Mechanisms of Aging”, Thomas, Springfield, 1966.Google Scholar
  10. Curtis, J.M. and Miller, K. Chromosomal aberrations of liver cells of guinea pigs. J. Gerontol. 26:292–293, 1971.PubMedGoogle Scholar
  11. Cutler, R.G. Transcription of unique and reiterated DNA sequence in mouse liver and brain tissues as a function of age. Exp. Gerontol. 10:37–59, 1975.PubMedCrossRefGoogle Scholar
  12. DeBoni, U., DeScott, J.W. and Crapper, D.R. Intracellular aluminum binding, A histochemical study. Histochemistry 40:31–37, 1974.CrossRefGoogle Scholar
  13. Douvas, A.S., Harrington, C.A. and Bonner, J. Major nonhistone proteins of rat liver chromatin: preliminary identification of myosin, actin, tubulin and tropomyosin. Proc. Natl. Acad. Sci. USA 72:3902–3906, 1975.PubMedCrossRefGoogle Scholar
  14. Freese, E. and Castel, M. Crosslinking of deoxyribonucleic acid by exposure to low pH. Biochim. Biophys. Acta 91:67–77, 1964.PubMedGoogle Scholar
  15. Gaudin, D., Gregg, R. and Yielding, K. Inhibition of DNA repair by co-carcinogens. Biochem. Biophys. Res. Commun. 48:945, 1972.PubMedCrossRefGoogle Scholar
  16. Glassman, T.A., Klopman, G. and Cooper, C. Use of the generalized perturbation theory to predict the interaction of purine nucleo-tides with metal ions. Biochemistry 12:5013–5019, 1973.PubMedCrossRefGoogle Scholar
  17. Gottschalk, A. Interaction between reducing sugars and amino acids under neutral and acidic conditions. Glycoproteins 5(part A): 144–157, 1972.Google Scholar
  18. Grossman, L., Brawn, A., Feldberg, R. and Mahler, I. Enzymatic Repair of DNA. Annual Rev. Biochem. 44:19–43, 1975.CrossRefGoogle Scholar
  19. Hart, R.W. and Setlow, R.B. Correlation between desoxyribonucleic and acid excision repair and lifespan in a number of mammalian species. Proc. Natl. Acad. Sci. USA 71:2169–2173, 1974.PubMedCrossRefGoogle Scholar
  20. Hayatsu, H. Bisulfite modification of nucleic acids and their constituents. Progress in Nucleic Acid Res. 16:75–124, 1976.CrossRefGoogle Scholar
  21. Herrmann, R.L., Bick, M.D., Dowling, L. and Russell, A.F. Age-related changes in a spontaneous reassociating fraction of mouse DNA. Mech. Age and Dev. 4:181–189, 1975.CrossRefGoogle Scholar
  22. Hoar, D.I. and Sargent, P. Chemical mutagen hypersensitivity in ataxia telangiectosia. Nature 261:590–592, 1976.PubMedCrossRefGoogle Scholar
  23. Iqbal, K., Wisniewski, H.M., Shelanski, M.L., Brostoff, S., Liwnicz, B.H. and Terry, R.D. Protein changes in senile dementia. Brain Res. 77:337–343, 1974.PubMedCrossRefGoogle Scholar
  24. Iqbal, K. Wisniewski, H.M. and Grundke-Iqbal, I., et al. Chemical pathology of neurofibrils. Neurofibrillary of Alzheimer pre-senile dementia. J. Histochem. Cytochem. 23:563–569, 1975.PubMedCrossRefGoogle Scholar
  25. Kay, D.W., Beamish, P. and Roth, M. Old age mental disorders in Newcastle-Upon-Tyne, Part I (A study of Prevalence). Brit. J. Psychiat. 110:146–158, 1964.PubMedCrossRefGoogle Scholar
  26. Kay, D.W. Epidemiological aspects of organic brain disease in the aged, Age and the Brain. Adv. Behav. Biol. 3:15–28, 1972.CrossRefGoogle Scholar
  27. Kurtz, D.I., Russell, A.P. and Sinex, F.M. Multiple peaks in the derivative melting curve of chromatin from animals of varying age. Mech. Age and Dev. 3:37–49, 1974.CrossRefGoogle Scholar
  28. LeBeux, Y.J. and Willemot, J. An ultrastructural study of the micro-filaments in rat brain by means of E-PTA staining and heavy micromyosin labeling, I. Cell Tissue Res. 160:1–36, 1975.PubMedGoogle Scholar
  29. LeBeux, Y.J. and Willemot, J. The Perikaryon, the dendrites and the axon, II. Cell Tissue Res. 160:37–68, 1975.PubMedGoogle Scholar
  30. Lindahl, T. and Myberg, B. Rate of depurination of native deoxy-ribonucleic acid. Biochemistry 11:3610–3618, 1972.PubMedCrossRefGoogle Scholar
  31. Lindahl, T. and Anderson, A. Rate of chain breakage at apurinic sites in double straned desoxyribonucleic acid. Biochemistry 11:3618–3623, 1972.PubMedCrossRefGoogle Scholar
  32. Ljungquist, S. and Lindahl, T. A mammalian endonuclease specific for apurinic sites in double stranded desoxyribonucleic acid. J. Biol. Chem. 249:1530–1535, 1974.PubMedGoogle Scholar
  33. Liwnicz, B.H., Kristensson, K., Wisniewski, H.M., Shelanski, M.L. and Terry, R.D. Observations on axoplasmic transport in rabbits with aluminum-induced neurofibrillary tangle. Brain Res. 80: 413–420, 1974.PubMedCrossRefGoogle Scholar
  34. O’Meara, A.R. and Herrmann, R.L. A modified mouse liver chromatin preparation displaying age-related differences in salt dissociation and template ability. Biochim. Biophys. Acta 269:419–427, 1972.PubMedGoogle Scholar
  35. Sauger, J.W. Presence of actin during chromosomal movement. Proc. Natl. Acad. Sci. USA 72:994–998, 1975.CrossRefGoogle Scholar
  36. Scheibel, M.E., Lindsay, R.D., Toiyasu, V. and Scheibel, A.B. Progressive dendritic changes in aging human cortex. Exper. Neurol. 47:393–403, 1975.Google Scholar
  37. Sinex, F.M. The mutation theory of aging. In: Theoretical Aspects of Aging, (Ed. M. Rockstein), Academic Press, New York, pp. 23–31, 1974.Google Scholar
  38. Sinex, F.M. Molecular genetics of aging. In: Handbook on the Biology of Aging, (Eds. C. Finch and L. Hayflick), Van Nostrand Reinhold, New York, 1977 (in press).Google Scholar
  39. Tas, S. Disulfide bonding in chromatin proteins with age and a suggested mechanism for aging and neoplasia. Exper. Geront. 11:17–24, 1976.CrossRefGoogle Scholar
  40. Terry, R.D. and Wisniewski, H.M. Structural and chemical changes of the aged human brain. In: Aging, Vol. 2, (Eds. S. Gershon and A. Raskin), Raven Press, New York, pp. 127–141, 1975.Google Scholar
  41. Upton, A.C. Ionizing radiation and the aging process. J. Gerontol. 12:306–313, 1957.PubMedGoogle Scholar
  42. Verly, W.G. and Paquett, Y. An endonuclease for depurinated DNA in rat liver. Canadian J. of Biochem. 51:1003–1009, 1973.CrossRefGoogle Scholar
  43. Wheeler, K.T. and Lett, J.T. On the possibility that DNA repair is related to age in nondividing cells. Proc. Natl. Acad. Sci. USA 71:1862–1865, 1974.PubMedCrossRefGoogle Scholar
  44. Wilkins, R.J. and Hart, R.W. Preferential DNA repair in human cell. Nature 247:35–36, 1974.PubMedCrossRefGoogle Scholar
  45. Wisenberg, R.C. and Deery, W.J. Role of nucleotide hydrolysis in microtubule assembly. Nature 263:35–36, 1976.Google Scholar
  46. Wisniewski, H. and Terry, R.D. Experimental colchicine encephalopathy. Induction of neurofibrillary degeneration. Laboratory Investigation 17:577–587, 1967.PubMedGoogle Scholar
  47. Wisniewski, H. and Terry, R.D. An experimental approach to the morphogenesis of neurofibrillary degeneration and the argyrophilic plaque. In: CIBA Foundation Symposium on Alzheimer’s Disease and Related Conditions, (Eds. G.E. Wolstenholme and M.O. O’Connor), Churchill, London, pp. 223–240, 1970.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • F. Marott Sinex
    • 1
  1. 1.Boston University School of MedicineBostonUSA

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