Chromatin in Aging Brain
Dementia is a major problem for the Veterans Administration and will become more so as the World War I veterans enter their seventies and eighties. Dementia and confusional states may occur for a number of reasons. However, in a large number of cases, perhaps half of those with severe memory loss show a pathology similar to that first described in patients with pre-senile dementia by Alzheimer, namely cortical atrophy, neurofibrillary tangles and senile plaques. For want of a better name, one is tempted to call dementia in the elderly with this type of pathology an Alzheimer’s type senile dementia, even though by definition Alzheimer’s disease is a pre-senile dementia. We may need a better name. Euphanisms cannot hide a problem on which little research is being done, which is costing more and more money, and placing more and more patients in chronic care institutions.
KeywordsNeurofibrillary Tangle Aging Brain Senile Dementia Nonhistone Protein Apurinic Site
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