Effects of Age-Related Random and Coordinated Loss of Memory Engrams on Error Rates During Memory Retrieval
Age-related memory dysfunction and attendant changes in that curious entity called “self”, as well as its perception by other selves and by itself, are among the most distressing of the changes that are intrinsic to the aging process. The amelioration of age related memory defects would seem best based on an understanding of how memory engrams are stored within and retrieved from the remarkable machine, the brain is. This paper briefly presents the essence of a mechanistic theory of memory storage and retrieval within and from the cerebral cortex, outlines potential sources of memory deficits implicit in this model and relates the above to recent anatomical, physiological, and mathematical observations. In particular, the implications of these observations with respect to differential effects between random cell attrition during aging and non-randomized cell loss (localized infarcts, senile dementia, etc.) are considered.
KeywordsMemory Retrieval Memory Space Senile Dementia Vertical Shaft Dendritic Shaft
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