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Effects of Age-Related Random and Coordinated Loss of Memory Engrams on Error Rates During Memory Retrieval

  • Bernard L. Strehler
Part of the Advances in Behavioral Biology book series (ABBI, volume 23)

Abstract

Age-related memory dysfunction and attendant changes in that curious entity called “self”, as well as its perception by other selves and by itself, are among the most distressing of the changes that are intrinsic to the aging process. The amelioration of age related memory defects would seem best based on an understanding of how memory engrams are stored within and retrieved from the remarkable machine, the brain is. This paper briefly presents the essence of a mechanistic theory of memory storage and retrieval within and from the cerebral cortex, outlines potential sources of memory deficits implicit in this model and relates the above to recent anatomical, physiological, and mathematical observations. In particular, the implications of these observations with respect to differential effects between random cell attrition during aging and non-randomized cell loss (localized infarcts, senile dementia, etc.) are considered.

Keywords

Memory Retrieval Memory Space Senile Dementia Vertical Shaft Dendritic Shaft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Bernard L. Strehler
    • 1
  1. 1.Division of Biological SciencesUniversity of Southern CaliforniaLos AngelesUSA

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