Differential Changes with Aging in Old and New Cortices
Throughout recorded history, the tragedy of aging has been, not that it comes, but that so often, it brings with it a host of changes in the psychosocial patterns of the individual, changes that may degrade and enfeeble the most gallant and competent. We cannot fail to share, as psychiatrists and as human beings, the pain of subject, family, and friends walking this bitter path together. But we must not lose sight of the fact that where substrate mechanisms can be identified, there is hope, if not of a way back, then at least of a gentler path which may give to more of the aged, some measure of those much-celebrated compensations of age.
KeywordsTemporal Lobe Epilepsy Entorhinal Cortex Layer Pyramid Dendrite Shaft Spine Loss
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- Brody, H. Aging of the Vertebrate Brain. In: Development and Aging in the Nervous System, (Ed. M. Rockstein), Academic Press, New York, pp. 121–133, 1973.Google Scholar
- Colonnier, M. In: Brain and Conscious Experience, (Ed. J. C. Eccles), Berlin-Heidelberg, N.Y. Springer, pp. 1–23, 1966.Google Scholar
- Corsellis, J. A. N. Mental Illness and the Aging Brain, Institute of Psychiatry, Mandstey Monograph #9 Oxford University Press, London, 1962.Google Scholar
- Hopker, W. Das Altern des Nucleus Dentatus, Z. Alternforsch. 5: 256–277, 1951.Google Scholar
- Lindsay, R.D. and Scheibel, A.B. Quantitative Analysis of Dendritic Branching Pattern of Dentate Granule Cells from Human Dentate Gyrus. Exp. Neurol., In Press.Google Scholar
- Mehraein, P., Yamada, M. and Tarmowska-Dziduszko, E. Quantitative Study on Dendrites and Dendritic Spines in Alzheimer’s Disease and Senile Dementia. In: Psychology and Pathology of Dendrites, (Ed. G. W. Kretzberg), Raven Press, N.Y., pp. 453–458, 1975.Google Scholar
- Milner, B. Disorders of Learning and Memory After Temporal-lobe Lesions in Man. Clin. Neurosurgery 19:421–446, 1972.Google Scholar
- Scheibel, M.E. and Scheibel, A.B. Structural Changes in the Aging Brain. In: Aging Vol. 1, (Eds. H. Brody et al.), Raven Press, New York, pp. 11–37, 1975.Google Scholar
- Simon, A. and Malamund, N. Comparison of Clinical and Neuropathologi-cal Findings in Geriatric Mental Illness. In: Psychiatric Disorders in the Aged, Geigy, Manchester, U.K., p. 322, 1965.Google Scholar
- Tomlinson, B.E. Morphological Brain Changes in Non-Dementia Old People. In: Aging of the Central Nervous System, (Eds. H. M. Van Praag and A. K. Kalverboen), Dr. Envon F. Bohm, N. Y., pp. 38–57, 1972.Google Scholar