Aluminum and the Genetic Apparatus in Alzheimer Disease

  • Donald R. Crapper
  • Umberto De Boni
Part of the Advances in Behavioral Biology book series (ABBI, volume 23)


Alzheimer disease, unlike certain other central nervous system degenerative processes, is associated with definite histopathological changes. Recent work from several laboratories suggests that it is possible to produce tissue changes in experimental animals resembling those found in Alzheimer disease. The important observation that the infective agent isolated from scrapie tissue induces neuritic plaques in mouse brain, offers a new model for the study of this puzzling manifestation of Alzheimer disease (Bruce and Fraser, 1975; Wisniewski et al., 1975). These observations further support the suspicion, long held by many investigators, that a viral like factor may be involved in the pathogenesis of this disease.


Alzheimer Disease Neurofibrillary Tangle Neuritic Plaque Aluminum Phosphate Neurofibrillary Degeneration 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Donald R. Crapper
    • 1
  • Umberto De Boni
    • 1
  1. 1.Departments of Physiology and MedicineUniversity of TorontoTorontoCanada

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