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Discriminative Stimulus Properties of Hallucinogens: Behavioral Assay of Drug Action

  • Donald M. Kuhn
  • Francis J. White
  • James B. Appel
Part of the Advances in Behavioral Biology book series (ABBI, volume 22)

Abstract

In this chapter we will review existing literature on the discriminative stimulus properties of several drugs which are often classified as hallucinogens. At the same time we ‘will try to answer several questions about the usefulness of this procedure. For example, can it be used as a specific behavioral assay or screening technique for hallucinogens? Can the mechanism of action of hallucinogenic drugs be effectively studied and, if so, can it tell us anything about the nature of hallucinations?

Keywords

Discriminative Stimulus Stimulus Property Transfer Test Drug Discrimination Training Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aghajanian, G. K.: LSD and CNS transmission. Ann. Rev. Pharmacol. 12: 157–168, 1972.PubMedCrossRefGoogle Scholar
  2. Barry, H., III.: Classification of drugs according to their discriminable effects in rats. Fed. Proc. 33: 1814–1824, 1974.PubMedGoogle Scholar
  3. Browne, R. G., Harris, R.T., and Ho, B.T.: Stimulus proper -ties of mescaline and N-methylated derivatives: difference in peripheral and direct central administration. Psychopharmacologia (Berl.) 34: 43–56, 1974.CrossRefGoogle Scholar
  4. Browne, R. G. and Ho, B.T.: Discriminative stimulus properties of mescaline: mescaline or metabolite? Pharmacol. Biochem. Behav. 3 : 109–114, 1975a.PubMedCrossRefGoogle Scholar
  5. Browne, R. G. and Ho, BT.: Role of serotonin in the discriminative stimulus properties of mescaline. Pharmacol. Biochem. Behav. 3: 429–435, 1975b.PubMedCrossRefGoogle Scholar
  6. Cameron, O. G. and Appel, J. B.: A behavioral and pharmacological analysis of some discriminable properties of d-LSD in rats. Psychopharmacologia (Berl.) 33: 117–134, 1973.CrossRefGoogle Scholar
  7. Colpaert, F. C., Niemegeers, C.J.E., and Janssen, P.A.J.: Theoretical and methodological considerations on drug discrimination learning. Psychopharmacologia (Berl.) 46: 169–177, 1976.CrossRefGoogle Scholar
  8. Freedman, D.X., Appel, J. B., Hartman, F. R., and Molliver, M. E.: Tolerance to behavioral effects of LSD-25 in rats. J. Pharmacol, exp. Ther. 143: 309–313, 1964.Google Scholar
  9. Greenberg, I., Kuhn, D.M., and Appel, J. B.: Behaviorally induced sensitivity to the discriminable properties of LSD. Psychopharmacologia (Berl.) 43: 229–232, 1975a.CrossRefGoogle Scholar
  10. Greenberg, I., Kuhn, D.M., and Appel, J. B.: Comparison of the discriminative stimulus properties of 9 THC and psilocybin in rats. Pharmacol. Biochem. Behav. 3: 931–934, 1975b.PubMedCrossRefGoogle Scholar
  11. Haertzen, C. A.: Subjective effects of the narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI). Psychopharmacologia (Berl.) 18: 366–377, 1970.CrossRefGoogle Scholar
  12. Harris, R. T. and Balster, R. L.: An analysis of the function of drugs in the stimulus control of operant behavior. In Stimulus Properties of Drugs, ed. by T. Thompson and R. Pickens, pp. 111–132, 1971.Google Scholar
  13. Hirschhorn, I.D., Hayes, R. L., and Rosecrans, J. A.: Discriminative control of behavior by electrical stimulation of the dorsal raphe nucleus: generalization to lysergic acid diethylamide (LSD). Brain Res. 86: 134–138, 1975.PubMedCrossRefGoogle Scholar
  14. Hirschhorn, I.D. and Rosecrans, J. A.: A comparison of the stimulus effects of morphine and lysergic acid diethylamide (LSD). Pharmacol. Biochem. Behav. 2: 361–366, 1974.PubMedCrossRefGoogle Scholar
  15. Hirschhorn, I.D. and Rosecrans, J. A.: Generalization of mor -phine and lysergic acid diethylamide (LSD) stimulus properties to narcotic analgesics. Psychopharmacology 47: 65–69, 1976.PubMedCrossRefGoogle Scholar
  16. Hirschhorn, I.D. and Winter, J.C.: Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli. Psychopharmacologia (Berl.) 22: 64–71, 1971.CrossRefGoogle Scholar
  17. Hirschhorn, I.D. and Winter, J.C.: Differences in the stimulus properties of barbital and hallucinogens. Pharmacol. Biochem. Behav. 3: 343–347, 1975.PubMedCrossRefGoogle Scholar
  18. Hollister, L. E.: Chemical psychosis. Ann. Rev. Med. 15: 203–214, 1964.PubMedCrossRefGoogle Scholar
  19. Hong, E., Sancillo, L.F., Vargas, R., and Pardo, E.G.: Similarities between the pharmacological actions of quipazine and serotonin. Life Sci. 6: 274–280, 1969.Google Scholar
  20. Jarbe, T.U.C., Johansson, J. O., and Henriksson, B. G.: Drug discrimination in rats: the effects of phencyclidine and ditran. Psychopharmacologia (Berl.) 42: 33–39, 1975.CrossRefGoogle Scholar
  21. Ketchem, J.S., Sidell, F.R., Crowell, E. B., Jr., Aghajanian, G.K., and Hayes, A. H., Jr.: Atropine, scopolomine, and ditran: comparative pharmacology and antagonists in man. Psychopharmacologia (Berl.) 28: 121–145, 1973.CrossRefGoogle Scholar
  22. Lovell, R. A. and Freedman, D. X.: Stereospecific receptor site for d-lysergic acid diethylamide in rat brain: effects of neurotransmitters, amine antagonists and other psychotropic drugs. Mol. Pharmacol. 12: 620–630, 1976.PubMedGoogle Scholar
  23. Overton, D. A.: Experimental methods for the study of state de -pendent learning. Fed. Proc. 33: 1800–1813, 1974.PubMedGoogle Scholar
  24. Schechter, M. D. and Rosecrans, J. A.: Lysergic acid diethylamide (LSD) as a discriminative cue: drugs with similar stimulus properties. Psychopharmacologia (Berl.) 26: 313–316, 1972.CrossRefGoogle Scholar
  25. Snyder, S.H., Faillace, L.A., and Weingartner, H.: DOM (STP), a new hallucinogenic drug, and DOET; effects in normal subjects. Amer. J. Psychiat. 125: 357–364, 1968.Google Scholar
  26. Snyder, S.H., Ungar, S., Blatchley, R., and Barfknecht, C.F.: Stereospecific actions of DOET (2, 5-dimethoxy-4-ethylam-phetamine) in man. Arch. Gen. Psychiat. 31: 103–106, 1974.PubMedCrossRefGoogle Scholar
  27. Tonge, S.R. and Leonard, B.E.: Partial antagonism of the behavioral and neurochemical effects of phencyclidine by drugs affecting monoamine metabolism. Psychopharmacologia (Berl.).24: 516–520, 1972.CrossRefGoogle Scholar
  28. Winter, J. C.: A comparison of the stimulus properties of mescaline and 2, 3, 4-trimethoxyphenylethylamine. J. Pharmacol. exp. Ther. 185: 101–107, 1973.PubMedGoogle Scholar
  29. Winter, J. C.: Hallucinogens as discriminative stimuli. Fed. Proc. 33: 1825–1832, 1974a.PubMedGoogle Scholar
  30. Winter, J. C.: The effects of 3, 4-dimethoxyphenylethylamine in rats trained with mescaline as a discriminative stimulus. J. Pharmacol, exp. Ther. 189: 741–747, 1974b.Google Scholar
  31. Winter, J. C.: The effects of 2, 5-dimethoxy-4-methylampheta-mine (DOM), 2, 5-dimethoxy-4-ethylamphetamine (DOET), d-amphetamine, and cocaine in rats trained with mescaline as a discriminative stimulus. Psychopharmacologia (Berl.) 44; 29–32, 1975.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Donald M. Kuhn
    • 1
  • Francis J. White
    • 1
  • James B. Appel
    • 1
  1. 1.Behavioral Pharmacology Laboratory, Department of PsychologyUniversity of South CarolinaColumbiaUSA

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