Advertisement

Discriminative Stimulus Properties of Benzodiazepines and Barbiturates

  • F. C. Colpaert
Part of the Advances in Behavioral Biology book series (ABBI, volume 22)

Abstract

In the present chapter we will present and discuss some data on the discriminative stimulus properties of benzodiazepines and pharmacologically related drugs. The first set of data refers to stimulus generalization experiments with benzodiazepines, barbiturates and neuroleptics in rats trained to discriminate 5 rag/kg chlor-diazepoxide from saline. The results obtained in that study (Colpaert et al., 1976b) are discussed in relation to a number of other pharmacologically relevant actions of the same drugs. A second set of data summarizes a large number of antagonism experiments the purpose of which was to identify somewhat more specifically the pharmacological action upon which the benzodiazepine cue is based. A major limitation of the results and conclusions presented here is, that they are derived from a single type of discrimination training (Colpaert et al., 197 6a) with only one training dose (5 mg/kg) of one drug (chlordiazepoxide) administered orally 30 min before test.

Keywords

Related Drug Training Dose GLUTET HIMIDE Cholinergic Agent Discriminative Stimulus Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. ACETO, M.D.: The antinicotinic effects of drugs with clinically useful sedative-antianxiety properties. Pharmacology 13: 458–464, 1975.PubMedCrossRefGoogle Scholar
  2. COLPAERT, F.C., NIEMEGEERS, C.J.E. AND JANSSEN, P.A.J.: Theoretical and methodological considerations on drug discrimination learning. Psychopharmacologia 46: 169–177, 1976a.PubMedCrossRefGoogle Scholar
  3. COLPAERT, F.C., DESMEDT, L.K.C. AND JANSSEN, P.A.J.: Discriminative stimulus properties of benzodiazepines, barbiturates and pharmacologically related drugs; relation to some intrinsic and anticonvulsant effects. Eur. J. Pharmacol. 37: 113–123, 1976b.PubMedCrossRefGoogle Scholar
  4. HAHN, F.: Analeptics. Pharmacol. Rev. 12:447–530, 1960.PubMedGoogle Scholar
  5. JÄRBE, T.U.C., JOHANSSON, J.O. AND HENRIKSSON, E.G.: Δ9-tetrahydrocannabinol and pentobarbital as discriminative cues in the mongolian gerbil (Meriones unguiculatus). Pharmacol. Biochem.Behav. 3:403–410, 1975.PubMedCrossRefGoogle Scholar
  6. JOHANSSON, J.O. AND JÄRBE, T. U. C.: Diazepam as a discriminative cue: its antagonism by bemegride. Eur. J. Pharmacol. 30: 372–375, 1975a.PubMedCrossRefGoogle Scholar
  7. JOHANSSON, J.O. AND JÄRBE, T.U.C.: Antagonism of pentobarbital induced discrimination in the gerbil. Psychopharmacologia 41: 225–228, 1975b.PubMedCrossRefGoogle Scholar
  8. OVERTON, D.A.: State-dependent learning produced by depressant and atropine-like drugs. Psychopharmacologia 10: 6–31, 1966.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • F. C. Colpaert
    • 1
  1. 1.Dept. PharmacologyJanssen Pharmaceutica Research LaboratoriesBeerseBelgium

Personalised recommendations