Discriminative Stimulus Properties of Benzodiazepines and Barbiturates
In the present chapter we will present and discuss some data on the discriminative stimulus properties of benzodiazepines and pharmacologically related drugs. The first set of data refers to stimulus generalization experiments with benzodiazepines, barbiturates and neuroleptics in rats trained to discriminate 5 rag/kg chlor-diazepoxide from saline. The results obtained in that study (Colpaert et al., 1976b) are discussed in relation to a number of other pharmacologically relevant actions of the same drugs. A second set of data summarizes a large number of antagonism experiments the purpose of which was to identify somewhat more specifically the pharmacological action upon which the benzodiazepine cue is based. A major limitation of the results and conclusions presented here is, that they are derived from a single type of discrimination training (Colpaert et al., 197 6a) with only one training dose (5 mg/kg) of one drug (chlordiazepoxide) administered orally 30 min before test.
KeywordsRelated Drug Training Dose GLUTET HIMIDE Cholinergic Agent Discriminative Stimulus Property
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