Drugs as Discriminable Events in Humans

  • Jack L. Altman
  • Jean-Marie Albert
  • Stephen L. Milstein
  • Isaac Greenberg
Part of the Advances in Behavioral Biology book series (ABBI, volume 22)


Behavioral pharmacology has generally focused upon one aspect of drug action, the unconditioned effect. This usually describes the influence of administered substanced upon either physiological (e.g., heart rate, temperature), behavioral (e.g., latency, discrimination ability), or psychological (e. g., mood, personality) measures (Efron, 1968). It is possible, however, to examine other drug properties. For example, the ability of compounds to function as reinforcers has been demonsträted in studies in which organisms will emit specified behaviors to obtain drugs (Schuster and Thompson, 1969; Brecher, 1972). In addition, there is now widespread evidence derived from the animal laboratory that ingested substances can act as stimulus events (Thompson and Pickens, 1971) controlling behavior in the


Will Emit Nonsense Syllable Lysergic Acid Discriminable Event Discriminative Property 
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  1. Altman, J.L.: Drugs and the production of temporal intervals in the rat. Prog. Neuropsychopharmacol., in press.Google Scholar
  2. Barry, H. III: Classification of drugs according to their discrim-inable effects in rats. Fed. Proc. 33: 1814–1824, 1974.PubMedGoogle Scholar
  3. Beautrais, A.L. and Marks, D.F.: A test of state dependency effects in marihuana intoxication for the learning of psychomotor tasks. Psychopharmacologia 46: 37–40, 1976.PubMedCrossRefGoogle Scholar
  4. Bindra, D.: Stimulus change reactions to novelty and response decrement. Psychol. Rev. 66: 96–103, 1959.PubMedCrossRefGoogle Scholar
  5. Brecher, E.M.: Licit and illicit drugs. Consumer’s Union, Mt. Vernon, New York, 1972.Google Scholar
  6. Brown, A., Feldman, R.S. and Moore, J.W.: Conditional discrimination learning based upon chlordiazepoxide: Dissociation or cue? J. Comp. Physiol. Psychol. 66: 211–215, 1968.PubMedCrossRefGoogle Scholar
  7. Bustamante, J.A., Rossello, A., Jordan, A., Pradera, E. and Insua, A.: Learning and drugs. Physiol. Behav. 3: 553–555, 1968.CrossRefGoogle Scholar
  8. Bustamante, J.A., Jordan, A., Vila, M., Gonzalez, A. and Insua, A.: State dependent learning in humans. Physiol. Behav. 5: 793–796, 1970.PubMedCrossRefGoogle Scholar
  9. Cheek, D.B.: Unconscious perception of meaningful sounds during surgical anesthesia as revealed under hypnosis, Am. J. Clin. Hyp. 1: 101–113, 1959.CrossRefGoogle Scholar
  10. Cohen, M.J. and Rickels, W.H.Jr.: Performance on a verbal learning task by subjects of heavy past marijuana usage. Psychopharmacolo-gia 37: 323–330, 1974.CrossRefGoogle Scholar
  11. Colpaert, F.C., Niemegeers, C.J.E. and Janssen, P.A.J.: Theoretical and methodological considerations on drug discrimination learning. Psychopharmacologia 46: 169–177, 1976.PubMedCrossRefGoogle Scholar
  12. Crow, L.T. and Ball, C: Alcohol state-dependency and autonomic reactivity. Psychophysiol. 12: 702–706, 1975.CrossRefGoogle Scholar
  13. Darley, C. F., Tinklenberg, J.R., Roth, W.T. and Atkinson, R.C.: The nature of storage deficits and state-dependent retrieval under marihuana. Psychopharmacologia 37: 139–149, 1974.PubMedCrossRefGoogle Scholar
  14. Diethelm, O. and Barr, R.M.: Experimental study of amnesic periods in acute alcohol intoxication. Psychiat. Neurol. 144: 5–14, 1962.CrossRefGoogle Scholar
  15. Efron, D.H.: Psychopharmacology: A review of progress, 1957–1967. U.S. Government Printing Office, Washington, D.C., 1968.Google Scholar
  16. Fischman, M.W., Schuster, C. R., Resnekov, L., Shick, J.F.E., Krasnegor, N.A., Fennell, W. and Freedman, D.X.: Cardiovascular and subjective effects of intravenous cocaine administration in humans. Arch. Gen. Psychiat. 33: 983–989, 1976.PubMedCrossRefGoogle Scholar
  17. Fraser, H.F., Van Horn, G.D., Martin, W.R., Wolbach, A.B. and Isbell, H.: Methods for evaluating addiction liability. (A) “Attitude” of opiate addicts toward opiate-like drugs; (B) A short-term “direct” addiction test. J. Pharmacol. Exp. Ther. 133: 371–387, 1961.PubMedGoogle Scholar
  18. Goldstone, S., Boardman, W.K. And Lhamon, W.T.: Effect of quinal barbitone, dextro-amphetamine, and placebo on apparent time. Br. J. Psychol. 49: 324–328, 1958.PubMedCrossRefGoogle Scholar
  19. Goodwin, D.W.: Alcoholic blackout and state-dependent learning. Fed. Proc. 33: 1833–1835, 1974.PubMedGoogle Scholar
  20. Goodwin, D.W., Powell, B., Bremer, D., Hoine, H. and Stern, J.: Alcohol and recall: State-dependent effects in man. Science 163: 1358–1360, 1969.PubMedCrossRefGoogle Scholar
  21. Goodwin, D.W., Powell, B., Hill, S.Y., Lieberman, W. and Viamontes, J.: Effects of alcohol on “dissociated” learning in alcoholics. J. Nerv. Ment. Dis. 158: 198–201, 1974.PubMedCrossRefGoogle Scholar
  22. Gorodetzky, C.W., Martin, W.R., Jasinski, D.R., Mansky, P.A. and Cone, E.J.: Human pharmacology of naltrexone. In: Developments in the Field of Drug Abuse, ed. by E. Senay, V. Shorty and H. Alksne, pp. 749–753, Schenkman Publishing Co., Cambridge, Mass., 1975.Google Scholar
  23. Greenwood, M.H., Friedel, J., Bond, A.J., Curzon, G. and Lader, M.H.: The acute effects of intravenous infusion of L-tryptophan in normal subjects. Clin. Pharmacol. The. 16: 455–464, 1974.Google Scholar
  24. Griffith, J.D., Nutt, J.G. and Jasinski, D.R.: A comparison of fenfluramine and amphetamine in man. Clin. Pharmacol. Ther. 18: 563–570, 1975.PubMedGoogle Scholar
  25. Hawkins, D.R., Pace, R., Pasternack, B. and Sandifer, M.G.Jr.: A multivariant psychopharmacologic study in normals. Psychosom. Med. 23: 1–17, 1961.PubMedGoogle Scholar
  26. Hill, S.Y., Schwin, R., Powell, B. and Goodwin, D.W.: State-dependent effects of marihuana on human memory. Nature 243: 241–242, 1973.PubMedCrossRefGoogle Scholar
  27. Hoffer, A. and Osmond, H.: The Hallucinogens, Academic Press, New York, 1967.Google Scholar
  28. Holliday, A.R. and Devery, W.J.: Effects of drugs on the performance of a task by fatigued subjects. Clin. Pharmacol. Ther. 3: 5–15, 1961.Google Scholar
  29. Hurst, P.M., Radlow, R., Chubb, N.C. and Bagley, S.K.: Effects of d-amphetamine on acquisition, persistence, and recall. Am. J. Psychol. 82: 307–319, 1969.PubMedCrossRefGoogle Scholar
  30. Hurst, P.M., Weidner, M.F., Radlow, R. and Ross, S.: Drugs and placebos: Drug guessing by normal volunteers. Psychol. Rep. 33: 683–694, 1973.PubMedCrossRefGoogle Scholar
  31. Jasinski, D.R., Martin, W.R. and Hoeldtke, R.D.: Effects of short-and long-term administration of pentazocine in man. Clin. Pharmacol. Ther. 11: 385–403, 1970.PubMedGoogle Scholar
  32. Jones, R.T.: Marihuana-induced “high”: Influence of expectation, setting and previous drug experience. Pharmacol. Rev. 23: 359–369, 1970.Google Scholar
  33. Kelleher, R.T. and Morse, W.H.: Determinants of the specificity of behavioral effects of drugs. Ergebnisse der Physiologie 60: 1–56, 1968.Google Scholar
  34. Klonoff, H.: Strategy and tactics of marijuana research. Can. Med. Assoc. J. 108: 145–150, 1973.PubMedGoogle Scholar
  35. Lasagna, L., von Felsinger, J.M. and Beecher, H.K.: Drug-induced mood changes in man. JAMA 157: 1006–1020, 1955.CrossRefGoogle Scholar
  36. Levinson, B.W.: States of awareness during general anesthesia. Br. J. Anesth. 37: 544–546, 1965.CrossRefGoogle Scholar
  37. Ley, P., Jain, V.K., Swinson, R.P., Eaves, D., Bradshaw, P.W., Kincey, J.A., Crowder, R. and Abbiss, S.: A state-dependent learning effect produced by amylobarbitone sodium. Br. J. Psychiat. 120: 511–515, 1972.CrossRefGoogle Scholar
  38. Manno, J.E., Kiplinger, G.R, Bennet, I.F., Haines, S. and Forney, R. B.: Comparative effects of smoking maribuana or placebo on human motor and mental performance. Clin. Pharmacol. Ther. 11: 808–815, 1970.PubMedGoogle Scholar
  39. Martin, W.R. and Fraser, H.F.: A comparative study of physiological and subjective effects of heroin and morphine administered intravenously in postaddicts. J. Pharmacol. Exp. Ther. 133: 388–399, 1961.PubMedGoogle Scholar
  40. Martin, W.R., Fraser, H.F., Gorodetzky, C.W. and Rosenberg, D.E.: Studies of the dependence-producing potential of the narcotic antagonist 2-cyclopropylmethyl-2 ‘-hydroxy-5,9-dimethyl-6,7-benzomor-phan (cyclazocine, WIN-20,740, ARC II-C-3). J. Pharmacol. Exp. Ther. 150: 426–436, 1965.PubMedGoogle Scholar
  41. Martin, W.R., Sloan, J.W., Sapira, J.D. and Jasinskt, D.R.: Physiologic, subjective, and behavioral effects of amphetamine, metham-phetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clin. Pharmacol. Ther. 12: 245–247, 1970.Google Scholar
  42. Martin, W.R., Jasinski, D.R. and Mansky, P.A.: Naltrexone, an antagonist for the treatment of heroin dependence. Arch. Gen. Psychiat. 28: 784–791, 1973.PubMedCrossRefGoogle Scholar
  43. Milstein, S.L., Maccannell, K., Karr, G. and Clark, S.: Marijuana-produced impairments in coordination. J. Nerv. Ment. Dis. 161: 26–31, 1975a.PubMedCrossRefGoogle Scholar
  44. Milstein, S.L., Maccannell, K., Karr, G. and Clark, S.: Marijuana-produced changes in pain tolerance: Experienced and non-experienced subjects. Int. Pharmacopsychiat. 10: 177–182, 1975b.Google Scholar
  45. Murphree, H.B.: Quantitative studies in humans on the antagonism of lysergic acid diethylamide by chlorpromazine and phenoxybenzamine. Clin. Pharmacol. Ther. 3: 314–320, 1962.PubMedGoogle Scholar
  46. Nahas, G.G.: Clinical pharmacology of cannabis sativa with special reference to delta-9-THC. Bull. Narcot. 25: 9–39, 1973.Google Scholar
  47. Osborn, A.G., Bunker, J.P., Cooper, L.M., Frank, G.S. and Hilgard, E. R.: Effects of thiopental sedation on learning and memory. Science 157: 574–576, 1967.PubMedCrossRefGoogle Scholar
  48. Overton, D.A.: State-dependent learning produced by alcohol and its relevance to alcoholism. In: The Biology of Alcoholism, vol. 2, Physiology and Behavior, ed. by B. Kissin and H. Begleiter, pp. 193–217, Plenum Press, New York, 1972.Google Scholar
  49. Overton, D.A.: State-dependent learning produced by addicting drugs. In: Opiate Addiction: Origins and Treatment, ed. by S. Fisher and A.M. Freedman, pp. 61–75, Winston & Sons, Washington, D.C., 1973.Google Scholar
  50. Peters, B.S., Lewis, E.G., Dustman, R.E., Straight, R.C. and Beck, E. C.: Sensory, perceptual, motor and cognitive functioning and subjective reports following oral administration of Δ9-tetrahydrocannabinol. Psychopharmacology 47: 141–148, 1976.CrossRefGoogle Scholar
  51. Resnick, R.B., Volavka, J., Freedman, A.M. and Thomas, M.: Studies of EN-1639A (Naltrexone): A new narcotic antagonist. Am. J. Psy-chiat. 131: 646–650, 1974.Google Scholar
  52. Rickels, W.H.Jr., Cohen, M.J., Whitaker, C.A. and Mcintyre, K.E.: Marijuana induced state-dependent verbal learning. Psychopharma-cologia 30: 349–354, 1973.CrossRefGoogle Scholar
  53. Roffman, M., Marshall, P., Silverstein, A., Karkalas, J., Smith, N. and Lal, H.: Failure to demonstrate “amphetamine state” controlling learned behavior in humans. In: Drug Addiction: Clinical and Socio- legal Aspects, vol. 2, ed. by J.M. Singh, L. Miller and H. LAL, pp. 53–57, Futura Publishing., Mt. Kisco, New York, 1972.Google Scholar
  54. Schuster, C. R. and Thompson, T.: Self-administration of and behavioral dependence on drugs. Annu. Rev. Pharmacol. 9: 483–502, 1969.PubMedCrossRefGoogle Scholar
  55. Steinberg, H.: “Abnormal behaviour” induced by nitrous oxide. Br. J. Psychol. 47: 183–194, 1956.PubMedCrossRefGoogle Scholar
  56. Stillman, R.C, Weingartner, H., Wyatt, R.J., Gillin, J.C. and Eich, J.: State-dependent (dissociative) effects of marihuana on human memory. Arch. Gen. Psychiat. 31: 81–85, 1974.PubMedCrossRefGoogle Scholar
  57. Stillman, R.C, Eich, J.E., Weingartner, H. and Wyatt, R.J.: Marihuana-induced state-dependent amnesia and its reversal by cueing. In: The Pharmacology of Marihuana, ed. by M.C Braude and S. Szara, pp. 453–456, Raven Press, New York, 1976.Google Scholar
  58. Storm, T. and Caird, W.K.: The effects of alcohol on serial verbal learning in chronic alcoholics. Psychon. Sci. 9: 43–44, 1967.Google Scholar
  59. Tarter, R.E.: Dissociate effects of ethyl alcohol. Psychon. Sci. 20: 342–343, 1970.Google Scholar
  60. Thompson, T. and Pickens, R.: Stimulus Properties of Drugs, Appleton Century Crofts, New York, 1971.Google Scholar
  61. Weil, A.T., Zinberg, N.E. and Nelsen, J.M.: Clinical and Psychological effects of marijuana in man. Science 162: 1234–1242, 1968.PubMedCrossRefGoogle Scholar
  62. Weingartner, H. and Faillace, L.A.: Alcohol state-dependent learning in man. J. Nerv. Ment. Dis. 153: 395–406, 1971.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Jack L. Altman
    • 1
  • Jean-Marie Albert
    • 2
  • Stephen L. Milstein
    • 1
  • Isaac Greenberg
    • 3
  1. 1.INRS-Santé, Université du QuébecHôpital L. H. LafontaineMontrealCanada
  2. 2.Institut de Recherches Psychiatriques de JolietteHôpital St-CharlesJolietteCanada
  3. 3.Alcohol and Drug Abuse Research CenterMcLean HospitalBelmontUSA

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