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Neurobiological Antagonism of Cocaine by Lithium

  • Arnold J. Mandell
  • Suzanne Knapp
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)

Abstract

Over the past several years our group has been examining the functional characteristics of the serotonergic biosynthetic system in the brain by subjecting it to a number of challenges including various drugs (Knapp, Mandell, 1972a, 1972b, 1973, 1975, in press; Knapp, Mandell, Geyer, 1974; Knapp, 1975; Knapp, Mandell, Bullard, 1975; Rogawski, Knapp, Mandell, 1974; Geyer, Dawsey, Mandell, 1975a; Geyer, Warbritton, Menkes, Zook, Mandell, 1975b; Geyer, Puerto, Dawsey, Knapp, Bullard, Mandell, in press, a) and environmental manipulations (Segal, Knapp, Kuczenski, Mandell, 1973; Geyer, Puerto, Menkes, Segal, Mandell, in press, b). A group of biochemical measures has evolved which appears to be useful in these explorations. As depicted in Fig. 1, they include: the high affinity uptake of tryptophan into serotonergic synaptosomes; the “amount” of soluble tryptophan hydroxylase activity in cell body and nerve ending regions (median raphe and striate cortex, respectively) after hypotonic lysis of the preparations; and the overall rate of conversion of tryptophan to serotonin (5-HT) by synaptosomes. Our experimental methods have been described in detail elsewhere (Knapp et al., 1974; Knapp, Mandell, 1975). The effects on these measures of cocaine in vitro and in vivo, alone and in combination with lithium chloride, will be described in this report.

Keywords

Nerve Ending Lithium Chloride Striate Cortex Tryptophan Hydroxylase Median Raphe 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Arnold J. Mandell
    • 1
  • Suzanne Knapp
    • 1
  1. 1.University of California at San DiegoLa JollaUSA

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