Distribution and Metabolism of Amphetamine in Tolerant Animals

  • Cynthia Moreton Kuhn
  • Saul M. Schanberg
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)


The physiological and behavioral responses of animals to amphetamine change in a complex way when they are treated chronically with this drug. A marked tolerance develops to many of the peripheral effects of amphetamine (such as hyperthermia and increased blood pressure) and to some effects mediated by the central nervous system (Kosman and Unna, 1968; Brodie, Cho, and Gessa, 1970b). However, potentiation of other aspects of the behavioral response to amphetamine (such as stereotyped behavior and increased locomotor activity) has been observed following chronic administration (Ellinwood, 1971; Ellinwood, Sudilovsky, and Nelson, 1972; Rech, Tilson, and Marquis, 1975; Segal, 1975). The biochemical mechanisms sub-serving these behavioral changes are not well understood. Studies of neurotransmitter mechanisms in animals treated chronically with amphetamine suggest that compensatory reactions of many processes are involved, including increased neurotransmitter synthesis, altered receptor sensitivity, and activation of inhibitory serotonergic pathways (Koda and Gibb, 1973; Mandell and Morgan, 1970; Sparber and Tilson, 1972).


Chronic Administration Stereotyped Behavior Increase Locomotor Activity Liquid Scintillation Spectrometry Chronic Amphetamine 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Cynthia Moreton Kuhn
    • 1
  • Saul M. Schanberg
    • 1
  1. 1.Duke University Medical CenterDurhamUSA

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