Behavioral Effects of Amphetamine in Brain Damaged Animals: Problems in the Search for Sites of Action

  • Stanley D. Glick
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)


Many investigators have studied brain lesion-induced changes in sensitivity to the behavioral effects of amphetamine (i.e., dl-amphetamine, d-amphetamine, methamphetamine) in animals. The majority of these studies have been concerned with determining a site or sites of action of amphetamine. It has usually been assumed (though not necessarily correctly) that damage to a site of action will decrease or abolish an effect of the drug. Although such an approach is seemingly straightforward, there have been a large number of contradictory reports, with “decreases”, “no effects”, and “increases” in sensitivity to amphetamine sometimes reported to follow lesions in the same brain region. Based on methodological considerations, an attempt will be made in this review to resolve some of this confusion. In addition, evidence that amphetamine enhances an intrinsic asymmetry in nigro-striatal function will be discussed. This action, it will be proposed, may be responsible for normal variations among animals in drug sensitivity before as well as after lesions.


Locomotor Activity Corpus Striatum Hypothalamic Lesion Side Preference Denervation Supersensitivity 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Stanley D. Glick
    • 1
  1. 1.Department of PharmacologyMount Sinai School of Medicine,CUNYNew YorkUSA

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