The Comparative Psychotogenic Effects of L-Dopa and ET-495
The ability of amphetamine and methylphenidate to cause a schizophreniform psychosis in non-schizophrenic individuals is one of the bases for the hypothesized relationship between dopaminergic hyperactivity and some psychotic states (Connell, 1958; Griffith, Cavanaugh, and Oates, 1970; Angrist and Gershon, 1970; Spensley and Rockwell, 1972; Bell, 1973). The demonstration that these same drugs caused florid exacerbation of symptomatology when administered to schizophrenics (Janowsky, El-Yousef, Davis, and Sekerke, 1973; Janowsky and Davis, 1974) gave impetus to this concept. However, amphetamine and methylphenidate clearly affect both norepinephrine and dopamine (Lewander, 1974; Scheel-Krüger, 1971; Ferris, Tang, and Maxwell, 1972) thereby making it difficult to specifically implicate dopaminergic mechanisms in their psychotogenic effects with certainty.
KeywordsBrief Psychiatric Rate Scales Auditory Hallucination Emotional Lability Paranoid Ideation Formal Thought Disorder
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