Effects of Intravenous Cocaine on MHPG Excretion in Man

  • Javaid I. Javaid
  • Haroutune Dekirmenjian
  • John M. Davis
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)


Although there is a substantial body of evidence on the behavioral and pharmacological effects of cocaine in animals, the clinical effects of this drug in man have only been described anecdotally. There are virtually no systematic studies of cocaine’s behavioral effects on man when given under controlled experimental conditions nor are there any studies of the biological mechanism by which cocaine produces these effects. Clinically, it is an agent that produces euphoria and in this respect is similar to amphetamine. Moreover, like amphetamine or methylphenidate, when taken in larger amounts, it can produce a paranoid psychosis. It is also abused in a manner similar to amphetamine. This paper is a collaborative work between the research unit at the Illinois State Psychiatric Institute and Drs. Fischman and Schuster at the University of Chicago. The latter workers report in this volume (Fischman, Schuster, and Krasnegor, 1976) the experimental protocol that they prepared when they administered injections of cocaine or placebo. Their work primarily concerns the subjective effects of cocaine and also its effects on cardiovascular measures and cognitive performance. The present paper is a companion report and presents our preliminary results on the pharmacological evidence concerning how cocaine produces its behavioral effects on a biochemical level.


Subjective Effect Cocaine Administration Control Experimental Condition Intravenous Cocaine Paranoid Psychosis 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Javaid I. Javaid
    • 1
  • Haroutune Dekirmenjian
    • 1
  • John M. Davis
    • 1
  1. 1.Illinois State Psychiatric InstituteChicagoUSA

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