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Cocaine: Blood Concentration and Physiological Effect After Intranasal Application in Man

  • Robert Byck
  • Peter Jatlow
  • Paul Barash
  • Craig Van Dyke
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)

Abstract

This paper reports preliminary results from a multidisciplinary study of the actions of cocaine in man. We are in the process of evaluating the relationship of blood concentrations of drug to physiological effect after intranasal application to man. This communication is divided into three parts. The first is a report of a method that allows determination of cocaine plasma concentrations reached after clinically effective doses in man (Jatlow and Bailey, 1975). The second part of the study is the presentation of the results of work with surgical patients who received cocaine as part of their ordinary clinical care (Van Dyke, Barash, Jatlow, and Byck, 1975). In these patients blood concentrations were determined after intranasal application of cocaine for anesthetic purposes. The third section of the paper reports blood concentrations found in normal subjects given cocaine as part of an experimental procedure in which a multiplicity of physiological measures are compared with the amount of cocaine present in the blood. Only preliminary physiological results are presented in this section. In addition we have studied the excretion of cocaine metabolites after intranasal application of various doses in surgical patients and experimental subjects and report the sensitivity of the EMIT method for detecting cocaine metabolites.

Keywords

Blood Concentration Nasal Mucosa Street User Isosorbide Dinitrate Morphine Sulfate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adriani, J.: The clinical pharmacology of local anesthetics, Clin. Pharmacol. Therap. 1, 645–673 (1960).Google Scholar
  2. Adriani, J. and Campbell, D.: The absorption of topically applied tetracaine and cocaine, Laryncoscope, St. Louis 68, 65–72 (1958).Google Scholar
  3. Adriani, J. and Campbell, D.: Fatalities following topical application of local anesthetics to mucous membranes, J. Am. med. Ass. 162, 1527–1530 (1956).CrossRefGoogle Scholar
  4. Berkowitz, B.A., Nagai, S.H., Yang, J.C., Hempstead, J., and Spector, S.: The disposition of morphine in surgical patients, Clin. Pharmacol. Therap. 17, 629–635 (1975).Google Scholar
  5. Campbell, D. and Adriani, J.: Absorption of local anesthetics, J. Am. med. Ass. 168, 873–877 (1958).CrossRefGoogle Scholar
  6. Erikssen, E., Englessen, S., Wahlquist, S., and Ortengren, B.: Study of the intravenous toxicity [of prilocainel in man and some in vitro studies on the distribution and absorbability, Acta Chir. Scand. 358, Suppl. 25 (1966).Google Scholar
  7. Halkin, H., Meffin, P., Melmon, K.L., and Rowland, M.: Influence of congestive heart failure on blood levels of lidocaine and its active monodeethylated metabolite, Clin. Pharmacol. Therap. 17, 669–676 (1975).Google Scholar
  8. Hill, E.H., Haertz, C.A., Wolbach, A.B., and Miner, E.J.: The Addiction Research Center Inventory: Appendix, Psychopharmacologia Berl. 4, 184–205 (1963).CrossRefGoogle Scholar
  9. Jatlow, P.I. and Bailey, D.N.: Gas-chromatographic analysis for cocaine in human plasma with use of a nitrogen detector, Clin. Chem. 21, 1918–1921 (1975).Google Scholar
  10. Misra, A.L., Nayak, P.K., Patel, M.N., Vadlamini, N.L., and Mulé, S.J.: Identification of norcocaine as a metabolite of [3H]-cocaine in rat brain, Experientia 30, 1312–1314 (1974).PubMedCrossRefGoogle Scholar
  11. Nayak, P.K., Misra, A.L., and Mula, S.J.: Physiologic disposition and metabolism of [3H1-cocaine in the rat, Fed. Proc. 33, 527 (1974).Google Scholar
  12. Nayak, P.K., Misra, A.L., and Mulé, S.J.: Physiological disposition and biotransformation of [3H]-cocaine in acute and chronically-treated rats, Fed. Proc. 34, 781 (1975).Google Scholar
  13. Post, R.M., Kotin, J., and Goodwin, F.K.: The effects of cocaine on depressed patients, Am. J. Psychiat. 131 (5), 511–517 (1974).PubMedGoogle Scholar
  14. Stenson, R.E., Constantino, R.T., and Harrison, D.C.: Interrelationships of hepatic blood flow, cardiac output, and blood levels of lidocaine in man, Circulation 43, 205–211 (1971).Google Scholar
  15. Thomson, P.D., Melmon, K.L., Richardson, J.A., Cohn, K., Steinbrunn, W., Cudihee, R., and Rowland, M.: Lidocaine pharmacokinetics in advanced heart failure, liver disease and renal failure in humans, Ann. intern. Med. 78, 499–508 (1973).PubMedGoogle Scholar
  16. Van Dyke, C., Barash, P., Jatlow, P., and Byck, R.: Cocaine: Plasma concentrations after intranasal application in man, Science in press.Google Scholar
  17. Dyke, C. and Byck, R.: Cocaine: 1884–1974. In: Cocaine and Other Stimulants. Ellinwood, E.H., Jr. and Kilbey, M.M., Eds. New York: Plenum Press, 1976.Google Scholar
  18. Woods, L.A., Cochin, J., Fornefeld, E.J., McMahon, F.G., and Seevers, M.H.: The estimation of amines in biological materials with critical data for cocaine and mescaline, J. Pharmac. exp. Ther. 101, 188–199 (1951).Google Scholar
  19. Woods, L.A., McMahon, F.G., and Seevers, M.H.: Distribution and metabolism of cocaine in the dog and rabbit, J. Pharmac. exp. Ther. 101, 200–204 (1951).Google Scholar
  20. Zuckerman, M., Lubin, B., Vogel, L., and Valerius, E.: Measurement of experimentally induced effects, J. Cons. Psychol. 28, 418–425 (1964).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Robert Byck
    • 1
  • Peter Jatlow
    • 1
  • Paul Barash
    • 1
  • Craig Van Dyke
    • 1
  1. 1.Yale University School of MedicineNew HavenUSA

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