Cocaine: Blood Concentration and Physiological Effect After Intranasal Application in Man

  • Robert Byck
  • Peter Jatlow
  • Paul Barash
  • Craig Van Dyke
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)


This paper reports preliminary results from a multidisciplinary study of the actions of cocaine in man. We are in the process of evaluating the relationship of blood concentrations of drug to physiological effect after intranasal application to man. This communication is divided into three parts. The first is a report of a method that allows determination of cocaine plasma concentrations reached after clinically effective doses in man (Jatlow and Bailey, 1975). The second part of the study is the presentation of the results of work with surgical patients who received cocaine as part of their ordinary clinical care (Van Dyke, Barash, Jatlow, and Byck, 1975). In these patients blood concentrations were determined after intranasal application of cocaine for anesthetic purposes. The third section of the paper reports blood concentrations found in normal subjects given cocaine as part of an experimental procedure in which a multiplicity of physiological measures are compared with the amount of cocaine present in the blood. Only preliminary physiological results are presented in this section. In addition we have studied the excretion of cocaine metabolites after intranasal application of various doses in surgical patients and experimental subjects and report the sensitivity of the EMIT method for detecting cocaine metabolites.


Blood Concentration Nasal Mucosa Street User Isosorbide Dinitrate Morphine Sulfate 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Robert Byck
    • 1
  • Peter Jatlow
    • 1
  • Paul Barash
    • 1
  • Craig Van Dyke
    • 1
  1. 1.Yale University School of MedicineNew HavenUSA

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