Role of Monoamine Neural Pathways in d-Amphetamine- and Methylphenidate-Induced Locomotor Activity

  • George R. Breese
  • Alan S. Hollister
  • Barrett R. Cooper
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)


Extensive efforts have been made during the past few years to correlate the pharmacological actions of d-amphetamine and other centrally-acting stimulants with neurochemical changes in brain. Initial work was directed toward the role of brain catecholamine systems in the complex actions of such centrally-acting stimulants. Studies showing that tyrosine hydroxylase inhibitors antagonized the behavioral actions of d-amphetamine led to the proposal that d-amphetamine is an indirectly acting amine and that an uninterrupted synthesis of catecholamines is required for its central actions (Weissman, Koe, and Tenen, 1966; Hanson, 1967). From experiments that utilized a dopamine-β-hydroxylase inhibitor, Randrup and Scheel-Krüger (1966) suggested that noradrenergic fibers were responsible for amphetamine-induced locomotor activity and that dopaminergic pathways were necessary for the stereotypies that occur after amphetamine administration. However, even though subsequent studies supported the view that dopamine was involved in the stereotypic behavior induced by d-amphetamine (Simpson and Iversen, 1971; Fibiger, Fibiger, and Zis, 1973), several investigators provided evidence that dopamine rather than norepinephrine release was essential for amphetamine-induced locomotor activity (Costa, Groppetti, and Naimzada, 1972; Carlsson, 1970; Breese, Cooper, and Smith, 1973; Hollister, Breese, and Cooper, 1974).


Locomotor Activity Locomotor Response Locomotor Stimulation Amphetamine Administration Brain Catecholamine 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • George R. Breese
    • 1
  • Alan S. Hollister
    • 1
  • Barrett R. Cooper
    • 1
  1. 1.Departments of Psychiatry and Pharmacology, Biological Sciences Research Center of the Child Development InstituteUniversity of North Carolina, School of MedicineChapel HillUSA

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