Differential Effects of Serotonin Depletion on Amphetamine-Induced Locomotion and Stereotypy

  • David S. Segal
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)


We have previously demonstrated that long-term administration of d-amphetamine in rats results in a progressive augmentation of stereotypy and/or locomotion, depending upon dose. Similar behavioral changes have been observed with repeated injection of 1-amphetamine and methylphenidate (Segal, unpublished data). Since amphetamine has been shown to exert effects on both catecholaminergic and serotonergic systems in the brain, it is conceivable that alterations in one or more of these neurochemical systems are responsible for the chronic amphetamine-induced behavioral augmentation. In fact, some evidence indicates that brain serotonin (5-HT) may be implicated since its depletion by either parachlorophenylalanine (PCPA) (Swonger and Rech, 1972; Mabry and Campbell, 1973; Breese, Cooper, and Mueller, 1974; Neuberg and Thut, 1974) or raphe lesion (Neill, Grant, and Grossman, 1972; Costall and Naylor, 1974; Jacobs, Wise, and Taylor, 1975; Geyer, Puerto, Menkes, Segal, and Mandell, 1976a) has been reported to enhance amphetamine-induced locomotion. Although the effects of 5-HT depletion on stereotypy are somewhat more equivocal (Rotrosen, Angrist, Wallach, and Gershon, 1972; Swonger and Rech, 1972; Weiner, Goetz, Westheimer, and Klawans, 1973; Breese et al., 1974; Costall and Naylor, 1974; Baldessarini, Amatruda, Griffin, and Gerson, 1975; Weiner, Goetz, and Klawans, 1975), it is possible that the behavioral augmentation observed with repeated administration of amphetamine is due, at least in part, to a progressive decrease in the functional activity of brain 5-HT systems.


Median Raphe Amphetamine Administration Neurochemical System Serotonin Depletion Midbrain Raphe 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • David S. Segal
    • 1
  1. 1.University of California, San DiegoLa JollaUSA

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