Chronic Administration of Stimulant Drugs: Response Modification

  • M. Marlyne Kilbey
  • Everett H. EllinwoodJr.
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)


Tolerance, lack of tolerance, and reverse tolerance of physiological and behavioral responses have been reported to develop with multiple administrations of stimulant drugs (Magos, 1969; Klawans, Corsett, and Dana, 1975; Kalant, Le Blanc, and Gibbins, 1971; Kosman and Unna, 1968; and Schuster, Dockens, and Woods, 1966). Stimulants that have been investigated include cocaine, amphetamine in its various isomers and analogs, and methylphenidate. Dosages have been used that produce sustained normal activity, hyperactivity, stereotyped behavior, anorexia, and hyperthermia. Changes in these measures with multiple administrations have been evaluated in man, monkey, cat, guinea pig, and mouse. As work in this area has developed, it has become increasingly apparent that a multiplicity of drug-, subject-, behavioral-, and environmental factors, as well as the interactions of these factors, must be specified if one hopes to correlate the observed changes in response to drug with changes in biological parameters in order to elucidate neurochemical mechanisms.


Chronic Administration Stereotyped Behavior Stimulant Drug Multiple Administration Stereotyped Response 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • M. Marlyne Kilbey
    • 1
  • Everett H. EllinwoodJr.
    • 1
  1. 1.Behavioral Neuropharmacology Section Department of PsychiatryDuke University Medical CenterDurhamUSA

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