Neural Substrates Mediating Amphetamine Responses
In a range of species amphetamine produces highly characteristic changes in behaviour. Rats have been studied most intensively, and in this species low doses (1.5mg/kg) of d-amphetamine induce a persistent running or locomotor behaviour. Higher doses (5mg/kg) lead to a disruption of motor behaviour, described as stereotyped, in which elements of the normal motor repertoire, such as sniffing, rearing, licking, biting and gnawing, are repeated in both abnormal order and frequency. In practical terms these behaviours are easy to quantify; and, very largely for this reason, amphetamine has often been selected as the “model” drug in experiments designed to elucidate the modes of action of stimulants.
KeywordsSubstantia Nigra Nucleus Accumbens Stereotyped Behaviour Locomotor Response Spontaneous Locomotor Activity
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