Progressive Changes in Behavior and Seizures Following Chronic Cocaine Administration: Relationship to Kindling and Psychosis

  • Robert M. Post
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)

Abstract

In this paper we will focus on the effects of repetitive cocaine administration on a variety of neurological, behavioral, and biochemical parameters. We will pay selective attention to the data suggesting that repetitive administration may be associated with increased effects on a variety of parameters, and will not review data suggesting that cocaine may produce tolerance in some systems. While we will present our findings of the effects of repetitive cocaine administration in laboratory animals, particularly the rat and rhesus monkey, they also appear relevant to the effects of stimulants in man. It has been reviewed in detail elsewhere that chronic administration of amphetamine-like stimulants may produce a paranoid psychosis difficult to distinguish from paranoid schizophrenia (Ellinwood, 1972; Connell, 1958; Snyder, 1973; Angrist, Gershon, 1970; Griffith, Cavanaugh, Held, Oates, 1970; Änggard, Jonsson, Hogmark, Gunne, 1973). Initial or lower doses of stimulants in a variety of patient populations, on the contrary, appear to elicit predominantly affective responses in the euphoric-dysphoric spectrum (Post, Kotin, Goodwin, 1974; Post, 1975; Resnick, Schwartz, Kestenbaum, Freedman, 1975). An adequate exposition of the mechanisms involved in the transition from predominantly affective symptoms to those in the schizophreniform spectrum with chronic stimulant administration, has not been adequately given.

Keywords

Dopamine Schizophrenia Cocaine Neurol Straw 

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Robert M. Post
    • 1
  1. 1.Section on Psychobiology, Adult Psychiatry BranchNational Institute of Mental HealthBethesdaUSA

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