Sensitization to Cocaine Following Chronic Administration in the Rat

  • Jeffrey S. Stripling
  • Everett H. EllinwoodJr.
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)


Reports of an augmented behavioral response to cocaine with repeated administration in laboratory animals have existed for some time. The earliest of these described an enhancement of both the psychomotor stimulant action (Downs and Eddy, 1932a; Tatum and Seevers, 1929) and convulsant effect (Downs and Eddy, 1932b; Tatum and Seevers, 1929) of cocaine. More recent studies have documented this sensitization with more quantitative measures, particularly with regard to the locomotor activity and stereotyped behavior associated with the psychomotor stimulant properties of cocaine (Kilbey and Ellinwood, 1976; Post, 1976; Ho, Taylor, Estevez, Englert, and McKenna, 1976). Other psychomotor stimulants, such as amphetamine, have also been shown to produce an increased response following chronic administration (Kilbey and Ellinwood, 1976; Klawans, Crossett, and Dana, 1975; Magos, 1969; Segal and Mandell, 1974). This sensitization and its underlying mechanisms are of particular interest because of their possible relationship to the gradual evolution of psychosis seen in humans during chronic use of these drugs (Ellinwood, 1967; Connell, 1958; Lewin, 1931; Ellinwood, Sudilovsky, and Nelson, 1973).


Chronic Administration Stereotyped Behavior Test Injection Behavioral Rate Chronic Cocaine 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Jeffrey S. Stripling
    • 1
  • Everett H. EllinwoodJr.
    • 1
  1. 1.Behavioral Neuropharmacology Section, Department of PsychiatryDuke University Medical CenterDurhamUSA

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