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Changes in Neuronal Activity in the Neostriatum and Reticular Formation Following Acute or Long-Term Amphetamine Administration

  • Philip M. Groves
  • George V. Rebec
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)

Abstract

There is now considerable evidence to suggest that the sequential patterns of hyperkinesia and behavioral stereotypes observed in a wide variety of species following an injection of amphetamines are due, in large measure, to a facilitation of catecholaminergic transmission in the central nervous system (e.g., as recently reviewed by Groves and Rebec, 1976). Additional recent work (e.g., Roberts, Zis, and Fibiger, 1975; Kelly, Seviour, and Iversen, 1975) further implicates the caudate-putamen, or neostriatum, and its dopaminergic input from the substantia nigra, pars compacta, and associated dopaminergic cell groups in the brainstem, in the expression of the psychomotor stimulant effects of amphetamine. The reticular formation of the brainstem is supplied, in part, by noradrenergic terminals and, as suggested by Bradley and associates (e.g., Bradley and Elkes, 1957; Bradley and Key, 1958), this area may contribute to the expression of amphetamine-induced electroencephalographic arousal. This view is consistent with the wide variety of evidence suggesting that the reticular formation of the brainstem mediates electroencephalographic and behavioral arousal (e.g., Moruzzi and Magoun, 1949; Lindsley, Bowden, and Magoun, 1949; Lindsley, Schriener, Knowles and Magoun, 1950; Segal and Mandell, 1970) and the elementary forms of plasticity that these phenomena exhibit (e.g., Sharpless and Hasper, 1956; Groves and Lynch, 1972; Groves, Wilson, and Miller, in press).

Keywords

Neuronal Activity Firing Rate Reticular Formation Neuronal Firing Spontaneous Firing Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Philip M. Groves
    • 1
  • George V. Rebec
    • 2
  1. 1.University of ColoradoBoulderUSA
  2. 2.School of MedicineUniversity of California, San DiegoLa JollaUSA

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