On Food Deprivation in Relation to Amphetamine Tolerance

  • Tommy Lewander
Part of the Advances in Behavioral Biology book series (ABBI, volume 21)


Previous studies on amphetamine tolerance in rats have shown that tolerance develops to some effects of the drug; e.g., hyperthermia, anorexia, increase in brain tryptophan concentrations(Lewander, 1971, 1974, unpublished observations), while not to others; e.g., motor hyperactivity, sterotyped behaviour (Lewander, 1971). In fact, reverse tolerance, viz. a progressive augmentation of sterotypies on chronic administration of low to medium doses of amphetamine, has been reported (Segal and Mandell, 1974).


Food Deprivation Free Tryptophan Time Response Curve Anorexigenic Effect Cumulative Food Intake 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Tommy Lewander
    • 1
  1. 1.Psychiatric Research Center, Ulleråker HospitalUniversity of UppsalaUppsalaSweden

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