Abstract
Previous studies on amphetamine tolerance in rats have shown that tolerance develops to some effects of the drug; e.g., hyperthermia, anorexia, increase in brain tryptophan concentrations(Lewander, 1971, 1974, unpublished observations), while not to others; e.g., motor hyperactivity, sterotyped behaviour (Lewander, 1971). In fact, reverse tolerance, viz. a progressive augmentation of sterotypies on chronic administration of low to medium doses of amphetamine, has been reported (Segal and Mandell, 1974).
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Lewander, T. (1977). On Food Deprivation in Relation to Amphetamine Tolerance. In: Ellinwood, E.H., Kilbey, M.M. (eds) Cocaine and Other Stimulants. Advances in Behavioral Biology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3087-5_10
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DOI: https://doi.org/10.1007/978-1-4684-3087-5_10
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